ReviewBiological trace element research2021
Insights into the Role of Magnesium Ions in Affecting Osteogenic Differentiation of Mesenchymal Stem Cells.
Review in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- The role of magnesium hydrogels in bone regeneration: a systematic review and meta-analysis.Journal of materials science. Materials in medicine · 2025Pooled it
- Multifunctional Roles of Magnesium Ions in Modulating Bone Regeneration-Related Cells.Bioengineering (Basel, Switzerland) · 2026Article
- Diet and Lipidomics Mediated Regulation of Mesenchymal Stem Cell Function: Diet, Omics and Stem Cell Connection.Biomolecules · 2026Review
- Temporal immunomodulation of CD4Science advances · 2026Article
- Graft-Free Sinus Lift Using a Resorbable Magnesium Membrane vs. Standard Grafting Protocol: A Bilateral Case Report with Histological Evaluation.Dentistry journal · 2026Article
- Immunomodulatory-osteogenic dual-functional nanofibers augment screw anchorage in osteoporotic bone.Materials today. Bio · 2026Article
- Mg-Hydroxyapatite Nanorods for Dual Intracellular Doxorubicin Delivery and Osteogenic-Associated BM-MSC Responses.ACS applied bio materials · 2026Article
- Magnesium ion implantation enhances the osseointegration and vascularization of 3D-Printed CoCrMo alloy scaffolds for load-bearing orthopedic applications.Bioactive materials · 2026Article
- Bioconvergence of sound-guided and supramolecular assembly strategies to create peptide-protein composite hydrogels with predictable shape-to-function features.Materials today. Bio · 2026Article
- Magnesium Phosphate Cements for Endodontic Applications: A Critical Review of Promise and Pitfalls.Iranian endodontic journal · 2026Review
- Review
- MBioactive materials · 2025Article
- Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Fabrication of BMSCs-affinity peptide functionalized blended hyaluronic acid/polydopamine nanofibrous scaffolds to controlled Mg ion release and improved osteogenic differentiations for accelerating bone regeneration.Journal of biological engineering · 2025Article
- Enhanced Osteogenesis and Antibacterial Properties of Ketoprofen-Loaded MgCu-MOF74-Coated Titanium Alloy for Bone Implant.Journal of functional biomaterials · 2025Article
- Poly-ε-caprolactone/chitosan/whitlockite electrospun bionic membrane conjugated with an E7 peptide for bone regeneration.Stem cell research & therapy · 2025Article
- Impact of Strontium, Magnesium, and Zinc Ions on the In Vitro Osteogenesis of Maxillary Sinus Membrane Stem Cells.Biological trace element research · 2025Article
- Internal fixation with biodegradable high purity magnesium screws in the treatment of ankle fracture.Journal of orthopaedic translation · 2025Article
- Overview of porous magnesium-based scaffolds: development, properties and biomedical applications.Materials futures · 2025Review
- Injectable photosensitive bone cement enhancing angiogenesis and osteogenic differentiation for the treatment of bone nonunion.APL bioengineering · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Bone marrow mesenchymal stem cells (MSCs) are multipotent stem cells with the ability to differentiate into bone-producing cells, which is essential for bone formation. Magnesium biomedical materials, such as biodegradable matters with osteoinductive properties, play a vital role in the osteogenic differentiation of MSCs. International and Chinese studies have shown that magnesium ions, which are produced by biodegradation, mainly achieve this effect by regulating the expression of genes and proteins associated with osteogenesis, activating multiple signal pathways, elevating autophagic activities, and adjusting the pH in the microenvironment. It is of great significance to study the regulatory mechanisms and identify the optimal conditions that how magnesium ions promote osteogenic differentiation of MSCs. In this study, we summarized the regulatory mechanisms noted above.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.