Evidence map›Paper›PMID 32453609›Full record

ReviewAnnals of medicine2020

Lipoprotein(a) in atherosclerosis: from pathophysiology to clinical relevance and treatment options.

Andreja Rehberger Likozar, Mark Zavrtanik, Miran Šebeštjen

2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Annals of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT04613167. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04613167 naunknown status

Genetic, Biochemical and Functional Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment Options

Ran2020Enrolled70Registered outcomes3Posted comparisons0ConditionsAcute Coronary Syndrome, Genetic Polymorphisms, Inflammation, LipoproteinemiaArmsAlirocumab, Control group, Evolocumab
Open the trial in the graph
NCT04993664 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Influence of Pelacarsen on Arterial Wall Properties and Risk Factors in Patients After Myocardial Infarction With High Lp(a) Values

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2021 to 2022Enrolled0ConditionsAcute Coronary Syndrome, Lipoproteinemia, Inflammation, Genetic PolymorphismsArmsPelacarsen (TQJ230), Placebo
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Review
  8. The biology of lipoprotein(a): From genetics to molecular mechanisms.European journal of clinical investigation · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Statins-Their Effect on Lipoprotein(a) Levels.Reviews in cardiovascular medicine · 2025
    Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Andreja Rehberger LikozarDepartment of Vascular Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Mark ZavrtanikDivision of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Miran ŠebeštjenDepartment of Vascular Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.ORCID 0000-0001-9907-3522
Ljubljana University Medical Centre · SIUniversity of Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein(a) (Lp(a)) was discovered more than 50 years ago, and a decade later, it was recognized as a risk factor for coronary artery disease. However, it has gained importance only in the past 10 years, with emergence of drugs that can effectively decrease its levels. Lp(a) is a low-density lipoprotein (LDL) with an added apolipoprotein(a) attached to the apolipoprotein B component

Indexed as

PCSK9 InhibitorsAnticholesteremic AgentsAtherosclerosisCholesterol, LDLCoronary Artery DiseaseHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLipoprotein(a)Proprotein Convertase 9Risk AssessmentAnticholesteremic AgentsCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsLipoprotein(a)PCSK9 InhibitorsPCSK9 protein, humanProprotein Convertase 9atherosclerosisLipoprotein(a)pathophysiologytreatment

Identifiers

PMID32453609
PMCPMC7877976
OpenAlexW3028901676

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.