Evidence map›Paper›PMID 32454934›Full record

ArticleOxidative medicine and cellular longevity2020

Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure.

Shaomin Yang, Haixiong Chen, Kuan Tan, Fusheng Cai, Yongxing Du, Weibiao Lv, Qiugen Hu, Yunzhao Hu, Yuli Huang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. α-Linolenic Acid and Risk of Heart Failure: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021
    Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Biomarkers of Oxidative Stress Tethered to Cardiovascular Diseases.Oxidative medicine and cellular longevity · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms.Frontiers in cell and developmental biology · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shaomin YangDepartment of Radiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.
Haixiong ChenDepartment of Radiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.
Kuan TanDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China.
Fusheng CaiDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China.
Yongxing DuDepartment of Radiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.
Weibiao LvDepartment of Laboratory Medicine, Shunde Hospital, Southern Medical University, Foshan, China.ORCID https://orcid.org/0000-0002-4216-5618
Qiugen HuDepartment of Radiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.
Yunzhao HuDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China.ORCID https://orcid.org/0000-0003-2299-3560
Yuli HuangDepartment of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China.ORCID https://orcid.org/0000-0001-5104-567X
The First People's Hospital of Shunde · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuantification of extracellular volume (ECV) fraction by cardiovascular magnetic resonance (CMR) has emerged as a noninvasive diagnostic tool to assess myocardial fibrosis. Secreted frizzled-related protein 2 (SFRP2) appears to play an important role in cardiac fibrosis. We aimed to evaluate the association between SFRP2 and myocardial fibrosis and the prognostic value of ECV fraction in patients with heart failure (HF).

methodsIn this prospective cohort study, 72 hospitalized adult patients (age ≥ 18 years) with severe decompensated HF were included. CMR measurements and T1 mapping were performed to calculate ECV fraction. Serum SFRP2 level was detected by an enzyme-linked immunosorbent assay kit. All patients were followed up, and the primary outcomes were composite events including all-cause mortality and HF hospitalization.

resultsDuring the median follow-up of 12 months, 27 (37.5%) patients experienced primary outcome events and had higher levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), SFRP2, and ECV fraction compared with those without events. In Pearson correlation analysis, levels of SFRP2 (

conclusionsHigher ECV fraction is associated with worsened prognosis in HF. SFRP2 is an independent biomarker for myocardial fibrosis. Further studies are needed to explore the potential therapeutic value of SFRP2 in myocardial fibrosis.

Indexed as

AdultArea Under CurveBiomarkersExtracellular SpaceFemaleHeart FailureHumansIncidenceMaleMembrane ProteinsMiddle AgedPatient DischargePrognosisProportional Hazards ModelsROC CurveSecreted Frizzled-Related ProteinsBiomarkersMembrane ProteinsSecreted Frizzled-Related ProteinsSFRP2 protein, human

Identifiers

PMID32454934
PMCPMC7229555
OpenAlexW3023126072

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.