Evidence map›Paper›PMID 32455951›Full record

ArticleInternational journal of molecular sciences2020

Identification of Inhibitors to

Tanira Matutino Bastos, Milena Botelho Pereira Soares, Caio Haddad Franco, Laura Alcântara, Lorenzo Antonini, Manuela Sabatino, Nicola Mautone, Lucio Holanda Freitas-Junior, Carolina Borsoi Moraes, Rino Ragno and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Tanira Matutino BastosInstituto Gonçalo Moniz, FIOCRUZ, Salvador 40296710, BA, Brazil.ORCID 0000-0001-5961-7572
Milena Botelho Pereira SoaresInstituto Gonçalo Moniz, FIOCRUZ, Salvador 40296710, BA, Brazil.
Caio Haddad FrancoDepartamento de Microbiologia, Universidade de São Paulo-USP, São Paulo 05508900, SP, Brazil.ORCID 0000-0003-2467-9401
Laura AlcântaraDepartamento de Microbiologia, Universidade de São Paulo-USP, São Paulo 05508900, SP, Brazil.ORCID 0000-0002-3374-7405
Lorenzo AntoniniRome Center for Molecular Design, Drug Chemistry and Technology Department, Sapienza University of Rome, 00185 Rome, Italy.
Manuela SabatinoRome Center for Molecular Design, Drug Chemistry and Technology Department, Sapienza University of Rome, 00185 Rome, Italy.
Nicola MautoneRome Center for Molecular Design, Drug Chemistry and Technology Department, Sapienza University of Rome, 00185 Rome, Italy.
Lucio Holanda Freitas-JuniorDepartamento de Microbiologia, Universidade de São Paulo-USP, São Paulo 05508900, SP, Brazil.
Carolina Borsoi MoraesDepartamento de Microbiologia, Universidade de São Paulo-USP, São Paulo 05508900, SP, Brazil.ORCID 0000-0002-0689-2770
Rino RagnoRome Center for Molecular Design, Drug Chemistry and Technology Department, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5399-975X
Dante RotiliDrug Chemistry and Technology Department, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-8428-8763
Sergio SchenkmanDepartamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039032, SP, Brazil.ORCID 0000-0001-9353-8480
Antonello MaiDrug Chemistry and Technology Department, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-9176-2382
Nilmar Silvio MorettiDepartamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039032, SP, Brazil.ORCID 0000-0003-0455-2497
Sapienza University of Rome · ITUniversidade de São Paulo · BRFundação Oswaldo Cruz · BRUniversidade Federal de São Paulo · BRIstituto Pasteur · IT

Funding

AIRC 2016 n. 19162Conselho Nacional de Desenvolvimento Científico Tecnológico (CNPq) 424729/2018-0Conselho Nacional de Desenvolvimento Científico Tecnológico (CNPq) 445655/2014-3Conselho Nacional de Desenvolvimento Científico Tecnológico (CNPq) 477143/2011-3Conselho Nacional de Desenvolvimento Científico Tecnológico (CNPq) INCT-VacinasFundação de Amparo à Pesquisa do Estado da Bahia PNX0002/2014Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/22031-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/09948-0PE-2013-02355271 02355271PRIN 2016 prot. 20152TE5PKPRIN 2017 prot. 2017JL8SRX
6 · The paper itself

Abstract

Chagas disease is an illness caused by the protozoan parasite

Indexed as

AnimalsCell LineChagas DiseaseDrug SynergismEpithelial CellsGroup III Histone DeacetylasesInhibitory Concentration 50Macaca mulattaMolecular Docking SimulationNitroimidazolesPhylogenyRecombinant ProteinsSirtuinsTrypanocidal AgentsTrypanosoma cruzibenzonidazoleGroup III Histone DeacetylasesNitroimidazolesRecombinant ProteinsSirtuinsTrypanocidal Agentsdeacetylationsirtuin inhibitorssirtuinsTrypanosoma cruzi

Identifiers

PMID32455951
PMCPMC7279216
OpenAlexW3026334821

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.