Evidence map›Paper›PMID 32456629›Full record

ArticleLipids in health and disease2020

Lipid profile and left ventricular geometry pattern in obese children.

Bojko Bjelakovic, Claudia Stefanutti, Vladimir Vukovic, Nebojsa Kavaric, Ljiljana Saranac, Aleksandra Klisic, Stevo Lukic, Sanja Stankovic, Maja Jovic, Sergej Prijic and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bojko BjelakovicClinical Center, Nis, Zorana Djindjica 48 Boulevard, Nis, 18000, Serbia. bojko968@gmail.com.ORCID http://orcid.org/0000-0002-7879-5793
Claudia StefanuttiExtracorporeal Therapeutic Techniques Unit, Lipid Clinic and Atherosclerosis Prevention Centre, Immunohematology and Transfusion Medicine, Department of Molecular Medicine, "Sapienza" University of Rome, "Umberto I" Hospital, Rome, Italy.
Vladimir VukovicInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.
Nebojsa KavaricPrimary Health Care Center, Podgorica, Montenegro.
Ljiljana SaranacClinical Center, Nis, Zorana Djindjica 48 Boulevard, Nis, 18000, Serbia.
Aleksandra KlisicPrimary Health Care Center, Podgorica, Montenegro.
Stevo LukicMedical faculty, University of Nis, Nis, Serbia.
Sanja StankovicCenter for Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.
Maja JovicMedical faculty, University of Nis, Nis, Serbia.
Sergej PrijicMedical faculty, University of Belgrade, Belgrade, Serbia.
Marko BjelakovicClinic of Pulmology, Clinical Center, Nis, Serbia.
Maciej BanachDepartment of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, 281/289 Rzgowska St., 93-338, Lodz, Poland. maciejbanach77@gmail.com.

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 175092
6 · The paper itself

Abstract

backgroundLeft ventricular hypertrophy (LVH) is an important risk factor for cardiovascular and all-cause mortality. Previous studies reported conflicting results concerning the relationship between serum lipid levels and left ventricular geometry pattern. We sought to explore the relationship between standard serum lipid profile measures with left ventricular geometry pattern in obese children. PATIENTS AND

methodsIn this cross-sectional study, a total of 70 obese children were examined. Fasting blood samples were taken to measure total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TGs), glucose, and insulin. Based on these values TG/HDL ratio, BMI and HOMA index were calculated. We also measured the average 24-h ambulatory systolic blood pressure (SBP) and two-dimensional (2/D) transthoracic echocardiography was performed to determine left ventricular mass index (LVMI) and relative wall thickness (RWT). Multiple regression analyses were conducted to explore relationships between study variables and the LVMI or RWT as outcome variables. The final model with LVMI included TG/HDL ratio, BMI, 24 h-average SBP, age and sex, while for the RWT we included BMI, insulin, age and sex.

resultsOur study included 70 children (65.71% boys and 34.29% girls) median age (14 years, IQR = 12-16)." We demonstrated independent and positive association of TG/HDL ratio, BMI and 24 h-average SBP with LVMI (effect = 3.65, SE = 1.32, p < 0.01; effect = 34.90, SE = 6.84, p < 0.01; effect = 0.32, SE = 0.12, p < 0.01, respectively). On the other hand, in model with RWT as outcome variable, only BMI and insulin were significantly linked (BMI: effect = 13.07, SE = 5.02, p = 0.01 Insulin: effect = 2.80, SE = 0.97).

conclusionIncreased TG/HDL ratio in obese children is associated with the development of eccentric left ventricular hypertrophy while increased BMI and insulin were associated with concentric left ventricular hypertophy.

Indexed as

AdolescentBody Mass IndexChildCholesterolCholesterol, HDLCholesterol, LDLCross-Sectional StudiesDyslipidemiasEchocardiographyFemaleHeart VentriclesHumansHypertrophy, Left VentricularInsulinLipidsMaleCholesterolCholesterol, HDLCholesterol, LDLInsulinLipidsTriglyceridesChildrenLeft ventricular mass indexObesityRelative wall thicknessTriglycerides

Identifiers

PMID32456629
PMCPMC7251900

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.