Evidence map›Paper›PMID 32457413›Full record

ArticleScientific reports2020

Connexin43 and connexin50 channels exhibit different permeability to the second messenger inositol triphosphate.

Virginijus Valiunas, Thomas W White

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. The impact of diabetes on tight junctions in cardiomyopathy dysfunction.Journal of diabetes and metabolic disorders · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Intercellular delivery of therapeutic oligonucleotides.Journal of drug delivery science and technology · 2022
    Article
  10. Mutations of CX46/CX50 and Cataract Development.Frontiers in molecular biosciences · 2022
    Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Virginijus ValiunasThe Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, NY, 11794, USA.
Thomas W WhiteThe Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, NY, 11794, USA. thomas.white@stonybrook.edu.
Stony Brook University · US

Funding

Lens Intercellular Communication Connexins and CataractsR01EY013163 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI WHITE, THOMAS W · 2000 to 2019
$6.2M
Age related changes in lens transport and cataractR01EY026911 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI THOMAS W WHITE · 2016 to 2026
$4.0M
MicroRNA permeability of connexin mutants related to genetic diseaseR01GM088181 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI VALIUNAS, VIRGINIJUS · 2011 to 2020
$2.8M
NEI NIH HHS R01 EY013163NEI NIH HHS R01 EY026911NIGMS NIH HHS R01 GM088181
6 · The paper itself

Abstract

Gap junction channels made of different connexins have distinct permeability to second messengers, which could affect many cell processes, including lens epithelial cell division. Here, we have compared the permeability of IP

Indexed as

CalciumConnexin 43Connexin 50ConnexinsHeLa CellsHumansInositol 1,4,5-TrisphosphateSecond Messenger SystemsCalciumConnexin 43Connexin 50ConnexinsGJA1 protein, humanInositol 1,4,5-Trisphosphate

Identifiers

PMID32457413
PMCPMC7251084
OpenAlexW3031421783

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.