Evidence map›Paper›PMID 32457534›Full record

ReviewNature reviews. Endocrinology2020

International consensus on the diagnosis and management of dumping syndrome.

Emidio Scarpellini, Joris Arts, George Karamanolis, Anna Laurenius, Walter Siquini, Hidekazu Suzuki, Andrew Ukleja, Andre Van Beek, Tim Vanuytsel, Serhat Bor and 10 more

3 registry-linked trialsAbstract readReviewConsensus Statement
In one paragraph

Review in Nature reviews. Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 134 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06789965 narecruitingnot on this mapstarted 2025, after this paper: background citation

Randomized Clinical Trial Comparing Two Surgical Techniques for the Treatment of Type III Obesity (BMI 40-50 kg/m2): Single Anastomosis Duodeno-ileal Bypass With Sleeve Gastrectomy (SADI-S) and Roux-en-Y Gastric Bypass (RY-GBP)

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2025 to 2030Enrolled450ConditionsObesityArmsSADI-S, RY-GBP
NCT06967571 narecruitingnot on this mapstarted 2026, after this paper: background citation

Reconstruction With a Lawrence-Hunt Jejunal Pouch for Upfront Total Gastrectomy - Study Protocol of a Prospective, Single-arm, Phase II Trial

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2026 to 2028Enrolled26ConditionsTotal Gastrectomy, Gastric CancerArmsJejunal Pouch reconstruction.
NCT07440706 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Prospective Randomized Study Evaluating the Efficacy and Safety of the iCan i3 Continuous Glucose Monitoring System in Post-Bariatric Patients With Late Dumping Syndrome

TypeinterventionalSponsorKaiser Clinic and HospitalRan2025 to 2026Enrolled60ConditionsDumping Syndrome, Post-bariatric HypoglycemiaArmsCan i3 Continuous Glucose Monitoring System
3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Uncut Roux-en-Y reconstruction after distal gastrectomy for gastric cancer.The Cochrane database of systematic reviews · 2024
    Pooled it
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  6. Systematic review of health-related quality of life (HRQoL) issues associated with gastric cancer: capturing cross-cultural differences.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022
    Pooled it
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  9. Trial
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  15. Review
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  17. Article
  18. Symptomatic reactive hypoglycemia is highly prevalent post-esophagectomy.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026
    Article
  19. Article
  20. Article

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Emidio ScarpelliniTranslational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (ChroMetA), Catholic University of Leuven, Leuven, Belgium.
Joris ArtsGastroenterology Division, St Lucas Hospital, Bruges, Belgium.
George Karamanolis2nd Department of Internal Medicine - Propaedeutic, Hepatogastroenterology Unit, Attikon University Hospital, Medical School, Athens University, Athens, Greece.ORCID http://orcid.org/0000-0001-9872-1276
Anna LaureniusDepartment of Gastrosurgical Research and Education, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9150-1876
Walter SiquiniPolitechnic University of Marche, "Madonna del Soccorso" General Hospital, San Benedetto del Tronto, Italy.
Hidekazu SuzukiDepartment of Gastroenterology and Hepatology, Tokai University School of Medicine, Isehara, Japan.
Andrew UklejaDivision of Gastroenterology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Andre Van BeekDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Tim VanuytselTranslational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (ChroMetA), Catholic University of Leuven, Leuven, Belgium.
Serhat BorDivision of Gastroenterology, Ege University School of Medicine, Izmir, Turkey.
Eugene CeppaDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-8368-2232
Carlo Di LorenzoDivision of Pediatric Gastroenterology, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-8982-0336
Marloes EmousDepartment of Bariatric and Metabolic Surgery, Medical Center Leeuwarden, Leeuwarden, Netherlands.
Heinz HammerDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Per HellströmDepartment of Medical Sciences, Gastroenterology/Hepatology, Uppsala University, Uppsala, Sweden.
Martine LavilleDepartment of Endocrinology, Claude Bernard University, Lyon, France.ORCID http://orcid.org/0000-0002-6252-9853
Lars LundellDepartment of Surgery Hospital, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Ad MascleeDepartment of Gastroenterology-Hepatology, University Hospital Leiden, Leiden, Netherlands.
Patrick RitzINSERM, U1027, 31073, Toulouse, France.
Jan TackTranslational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (ChroMetA), Catholic University of Leuven, Leuven, Belgium. jan.tack@med.kuleuven.ac.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal surgery. We initiated a Delphi consensus process with international multidisciplinary experts. We defined the scope, proposed statements and searched electronic databases to survey the literature. Eighteen experts participated in the literature summary and voting process evaluating 62 statements. We evaluated the quality of evidence using grading of recommendations assessment, development and evaluation (GRADE) criteria. Consensus (defined as >80% agreement) was reached for 33 of 62 statements, including the definition and symptom profile of dumping syndrome and its effect on quality of life. The panel agreed on the pathophysiological relevance of rapid passage of nutrients to the small bowel, on the role of decreased gastric volume capacity and release of glucagon-like peptide 1. Symptom recognition is crucial, and the modified oral glucose tolerance test, but not gastric emptying testing, is useful for diagnosis. An increase in haematocrit >3% or in pulse rate >10 bpm 30 min after the start of the glucose intake are diagnostic of early dumping syndrome, and a nadir hypoglycaemia level <50 mg/dl is diagnostic of late dumping syndrome. Dietary adjustment is the agreed first treatment step; acarbose is effective for late dumping syndrome symptoms and somatostatin analogues are preferred for patients who do not respond to diet adjustments and acarbose.

Indexed as

AcarboseBariatric SurgeryBlood GlucoseDiet TherapyDumping SyndromeEsophagusEvidence-Based MedicineGastrectomyGastric EmptyingGastrointestinal HormonesHumansMealsPostoperative ComplicationsPractice Guidelines as TopicQuality of LifeStomachAcarboseBlood GlucoseGastrointestinal Hormones

Identifiers

PMID32457534
PMCPMC7351708

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.