Evidence map›Paper›PMID 32457616›Full record

ReviewFrontiers in pharmacology2020

Role of Resolvins in the Inflammatory Resolution of Neurological Diseases.

Chunrong Li, Xiujuan Wu, Shan Liu, Donghui Shen, Jie Zhu, Kangding Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Chunrong LiNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China.
Xiujuan WuNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China.
Shan LiuNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China.
Donghui ShenNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China.
Jie ZhuNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China.
Kangding LiuNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China.
Jilin University · CNFirst Hospital of Jilin University · CNKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The occurrence of neurological diseases including neurodegenerative disorders, neuroimmune diseases, and cerebrovascular disorders is closely related to neuroinflammation. Inflammation is a response against infection or injury. Genetic abnormalities, the aging process, or environmental factors can lead to dysregulation of the inflammatory response. Our immune system can cause massive damage when the inflammatory response becomes dysregulated. Inflammatory resolution is an effective process that terminates the inflammatory response to maintain health. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are omega-three polyunsaturated fatty acids that play a crucial regulatory role in the development of inflammation. Resolvins (Rvs) derived from EPA and DHA constitute the Rvs E and Rvs D series, respectively. Numerous studies on the effect of Rvs over inflammation using animal models reveal that they have both anti-inflammatory and pro-resolving capabilities. Here, we review the current knowledge on the classification, biosynthesis, receptors, mechanisms of action, and role of Rvs in neurological diseases.

Indexed as

inflammationneurodegenerative disordersneuroimmune diseasesneurological diseasesresolvins

Identifiers

PMID32457616
PMCPMC7225325
OpenAlexW3021710773

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.