Evidence map›Paper›PMID 32460776›Full record

ArticleBMC veterinary research2020

Association of genetic polymorphisms related to Johne's disease with estimated breeding values of Holstein sires for milk ELISA test scores.

Sanjay Mallikarjunappa, Flavio S Schenkel, Luiz F Brito, Nathalie Bissonnette, Filippo Miglior, Jacques Chesnais, Michael Lohuis, Kieran G Meade, Niel A Karrow

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Application of Genomic Selection in Beef Cattle Disease Prevention.Animals : an open access journal from MDPI · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Sanjay MallikarjunappaCentre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Flavio S SchenkelCentre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Luiz F BritoDepartment of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Nathalie BissonnetteAgriculture and Agri-Food Canada, Sherbrooke Research and Development Centre, Sherbrooke, QC, J1M 0C8, Canada.
Filippo MigliorCentre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Jacques ChesnaisThe Semex Alliance, Guelph, ON, N1G 3Z2, Canada.
Michael LohuisThe Semex Alliance, Guelph, ON, N1G 3Z2, Canada.
Kieran G MeadeAnimal and Bioscience Research Department, Teagasc, Grange, Co. Meath, Ireland. Kieran.Meade@teagasc.ie.ORCID http://orcid.org/0000-0002-3051-8586
Niel A KarrowCentre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
University of Guelph · CADigital Research Alliance of CanadaTeagasc - The Irish Agriculture and Food Development Authority · IEAgriculture and Agri-Food Canada · CAPurdue University West Lafayette · US

Funding

Teagasc NA
6 · The paper itself

Abstract

backgroundJohne's disease (JD) is a chronic intestinal inflammatory disease caused by Mycobacterium avium subsp. paratuberculosis (MAP) infection in ruminants. Since there are currently no effective vaccine or treatment options available to control JD, genetic selection may be an alternative strategy to enhance JD resistance. Numerous Single Nucleotide Polymorphisms (SNPs) have been reported to be associated with MAP infection status based on published genome-wide association and candidate gene studies. The main objective of this study was to validate these SNPs that were previously identified to be associated with JD by testing their effect on Holstein bulls' estimated breeding values (EBVs) for milk ELISA test scores, an indirect indicator of MAP infection status in cattle.

resultsThree SNPs, rs41810662, rs41617133 and rs110225854, located on Bos taurus autosomes (BTA) 16, 23 and 26, respectively, were confirmed as significantly associated with Holstein bulls' EBVs for milk ELISA test score (FDR < 0.01) based on General Quasi Likelihood Scoring analysis (GQLS) analysis. Single-SNP regression analysis identified four SNPs that were associated with sire EBVs (FDR < 0.05). This includes two SNPs that were common with GQLS (rs41810662 and rs41617133), with the other two SNPs being rs110494981 and rs136182707, located on BTA9 and BTA16, respectively.

conclusionsThe findings of this study validate the association of SNPs with JD MAP infection status and highlight the need to further investigate the genomic regions harboring these SNPs.

Indexed as

AnimalsBreedingCattleCattle DiseasesDisease ResistanceEnzyme-Linked Immunosorbent AssayGenome-Wide Association StudyMaleMilkMycobacterium avium subsp. paratuberculosisParatuberculosisPolymorphism, Single NucleotideCattleJohne’s diseaseParatuberculosisSNP validation

Identifiers

PMID32460776
PMCPMC7254716
OpenAlexW3032173921

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.