Evidence map›Paper›PMID 32466148›Full record

ReviewJournal of clinical medicine2020

Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis.

Achraf Ammar, Khaled Trabelsi, Omar Boukhris, Bassem Bouaziz, Patrick Müller, Jordan M Glenn, Nicholas T Bott, Notger Müller, Hamdi Chtourou, Tarak Driss and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Dietary Flavonoids and Human Cognition: A Meta-Analysis.Molecular nutrition & food research · 2022
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  13. The acute effects of Zensera™ (Therapeutic advances in psychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Achraf AmmarInstitute of Sport Sciences, Otto-von-Guericke University, 39104 Magdeburg, Germany.
Khaled TrabelsiHigh Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia.ORCID 0000-0003-2623-9557
Omar BoukhrisHigh Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia.ORCID 0000-0002-2861-0164
Bassem BouazizHigher Institute of Computer Science and Multimedia of Sfax, University of Sfax, Sfax 3000, Tunisia.
Patrick MüllerGerman Center for Neurodegenerative Diseases (DZNE), 39104 Magdeburg, Germany.
Jordan M GlennExercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA.
Nicholas T BottNeurotrack Technologies, 399 Bradford St, Redwood City, CA 94063, USA.
Notger MüllerGerman Center for Neurodegenerative Diseases (DZNE), 39104 Magdeburg, Germany.
Hamdi ChtourouHigh Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia.ORCID 0000-0002-5482-9151
Tarak DrissInterdisciplinary Laboratory in Neurosciences, Physiology and Psychology: Physical Activity, Health and Learning (LINP2-2APS), UFR STAPS, UPL, Paris Nanterre University, 92000 Nanterre, France.
Anita HökelmannInstitute of Sport Sciences, Otto-von-Guericke University, 39104 Magdeburg, Germany.
University of Sfax · TNGerman Center for Neurodegenerative Diseases · DENeurotrack Technologies (United States) · USOtto-von-Guericke-Universität Magdeburg · DEUniversité Paris Nanterre · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextAffecting older and even some younger adults, neurodegenerative disease represents a global public health concern and has been identified as a research priority. To date, most anti-aging interventions have examined older adults, but little is known about the effects of polyphenol interventions on brain-related aging processes in healthy young and middle-aged adults.

objectiveThis systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in young and middle-aged adults. In July 2019, two electronic databases (PubMed and Web of Science) were used to search for relevant trials examining the effect of acute or chronic (poly)phenol-rich supplementation on cognitive function and neuroprotective measures in young and middle-aged adults (<60 years old). A total of 4303 records were screened by two researchers using the PICOS criteria. Fifteen high quality (mean PEDro score = 8.8 ± 0.58) trials with 401 total participants were included in the final analyses. Information on treatment, study design, characteristics of participants, outcomes and used tools were extracted following PRISMA guidelines. When items were shown to be sufficiently comparable, a random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. The meta-analysis indicated that (poly)phenol supplementation significantly increased brain-derived neurotrophic factor (ES = 3.259,

conclusionThis meta-analysis provides promising findings regarding the usefulness of polyphenol-rich intervention as an inexpensive approach for enhancing circulation of pro-cognitive neurotrophic factors. These beneficial effects appear to depend on the supplementation protocols. An early acute and/or chronic application of low- to high-dose phenolic components with high bioavailability rates (≥30%) at a younger age appear to provide more promising effects.

Indexed as

braincognitionmeta-analysisneuroplasticitypolyphenols

Identifiers

PMID32466148
PMCPMC7290428
OpenAlexW3026111115

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.