Evidence map›Paper›PMID 32467166›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish.

Kimberly Mitchell, Wo Su Zhang, Chunyu Lu, Binbin Tao, Lu Chen, Wei Hu, Vance L Trudeau

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
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  5. Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH-RH in Teleosts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
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  14. Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish.International journal of environmental research and public health · 2023
    Article
  15. Article
  16. Article
  17. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Kimberly MitchellDepartment of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Wo Su ZhangDepartment of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Chunyu LuDepartment of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Binbin TaoState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, The Innovation Academy of Seed Design, Chinese Academy of Sciences, 430072 Wuhan, China.ORCID 0000-0002-8187-7052
Lu ChenState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, The Innovation Academy of Seed Design, Chinese Academy of Sciences, 430072 Wuhan, China.ORCID 0000-0002-3830-3299
Wei HuState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, The Innovation Academy of Seed Design, Chinese Academy of Sciences, 430072 Wuhan, China trudeauv@uottawa.ca huwei@ihb.ac.cn.ORCID 0000-0002-6475-6427
Vance L TrudeauDepartment of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada; trudeauv@uottawa.ca huwei@ihb.ac.cn.ORCID 0000-0002-0845-9444
University of Ottawa · CAChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The luteinizing hormone surge is essential for fertility as it triggers ovulation in females and sperm release in males. We previously reported that secretoneurin-a, a neuropeptide derived from the processing of secretogranin-2a (Scg2a), stimulates luteinizing hormone release, suggesting a role in reproduction. Here we provide evidence that mutation of the

Indexed as

FertilityMating Preference, AnimalMutationAnimalsFemaleGonadotropin-Releasing HormoneHypothalamusLuteinizing HormoneMaleNeuropeptidesOvipositionOvulationPituitary GlandSecretogranin IIZebrafishZebrafish ProteinsGonadotropin-Releasing HormoneLuteinizing HormoneNeuropeptidesscg2a protein, zebrafishscg2b protein, zebrafishSecretogranin IIsecretoneurinZebrafish Proteinsbehaviorovulationreproductionsecretogranin-2secretoneurin

Identifiers

PMID32467166
PMCPMC7293709
OpenAlexW3032374457

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.