Evidence map›Paper›PMID 32475820›Full record

ArticleThe Journal of biological chemistry2020

Diabetes enhances translation of

Sadie K Dierschke, Allyson L Toro, William P Miller, Siddharth Sunilkumar, Michael D Dennis

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Glycosylation of the retina.Biochemical Society transactions · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Regulations of Retinal Inflammation: Focusing on Müller Glia.Frontiers in cell and developmental biology · 2022
    Review
  14. Feedback Regulation ofInternational journal of molecular sciences · 2021
    Article
  15. Retinol-binding protein 4 mRNA translation in hepatocytes is enhanced by activation of mTORC1.American journal of physiology. Endocrinology and metabolism · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sadie K DierschkeDepartment of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Allyson L ToroDepartment of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
William P MillerDepartment of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-0157-6389
Siddharth SunilkumarDepartment of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-3271-932X
Michael D DennisDepartment of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA mdennis@psu.edu.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

Shared Resource CoresP01HL107153 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ZHANG, HUI · 2011 to 2017
$16.8M
Targeting the Etiology of Diabetic RetinopathyR01EY029702 · NEI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DENNIS, MICHAEL D. · 2019 to 2023
$2.0M
NEI NIH HHS R01 EY029702NHLBI NIH HHS P01 HL107153
6 · The paper itself

Abstract

Activation of the immune costimulatory molecule cluster of differentiation 40 (CD40) in Müller glia has been implicated in the initiation of diabetes-induced retinal inflammation. Results from previous studies support that CD40 protein expression is elevated in Müller glia of diabetic mice; however, the mechanisms responsible for this increase have not been explored. Here, we evaluated the hypothesis that diabetes augments translation of the

Indexed as

Protein BiosynthesisAdaptor Proteins, Signal TransducingAnimalsCD40 AntigensCell Cycle ProteinsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Ependymoglial CellsEukaryotic Initiation FactorsFemaleGene Expression Regulation, EnzymologicMaleMiceMice, KnockoutNitric Oxide Synthase Type IIRNA, MessengerAdaptor Proteins, Signal TransducingCD40 AntigensCell Cycle ProteinsEif4ebp1 protein, mouseEif4ebp2 protein, mouseEukaryotic Initiation FactorsNitric Oxide Synthase Type IINos2 protein, mouseRNA, Messengercluster of differentiation 40 (CD40)diabeteseukaryotic translation initiation factor 4E–binding protein 1 (eIF4EBP1)inflammationmRNA translationMüller cellO-GlcNAcylationpost-translational modificationretinathiamet G

Identifiers

PMID32475820
PMCPMC7397109
OpenAlexW3030010904

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.