Evidence map›Paper›PMID 32479651›Full record

ArticleClinical and experimental immunology2020

Hypomethylation of Notch1 DNA is associated with the occurrence of uveitis.

H Wei, X Yin, H Tang, Y Gao, B Liu, Q Wu, Q Tian, Y Hao, H Bi, D Guo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. New perspectives on DNA methylation modifications in ocular diseases.International journal of ophthalmology · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

H WeiShandong University of Traditional Chinese Medicine, Jinan, China.
X YinShandong University of Traditional Chinese Medicine, Jinan, China.
H TangShandong University of Traditional Chinese Medicine, Jinan, China.
Y GaoShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Shandong, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities, Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, China.
B LiuDepartment of Blood Transfusion, Linyi People's Hospital, Linyi, China.
Q WuAffiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Q TianAffiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Y HaoShandong University of Traditional Chinese Medicine, Jinan, China.
H BiShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Shandong, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities, Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, China.
D GuoShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Shandong, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities, Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, China.ORCID 0000-0002-1712-0055
Shandong University of Traditional Chinese Medicine · CNShandong Shierming Eye Hospital · CNLinyi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveitis is a serious intra-ocular inflammatory disease that can lead to visual impairment even blindness worldwide. Notch signaling can regulate the differentiation of naive CD4

Indexed as

AdolescentAdultCells, CulturedCytokinesDioxygenasesDNADNA-Binding ProteinsDNA MethylationFemaleHumansMaleProto-Oncogene ProteinsReceptor, Notch1Th17 CellsT-Lymphocytes, RegulatoryUveitisCytokinesDioxygenasesDNADNA-Binding ProteinsNOTCH1 protein, humanProto-Oncogene ProteinsReceptor, Notch1TET2 protein, humanhypomethylationNotch1Th17Treguveitis

Identifiers

PMID32479651
PMCPMC7419911
OpenAlexW3029998812

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.