Evidence map›Paper›PMID 32483202›Full record

ArticleScientific reports2020

Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.

Eckhard U Alt, Philipp M Wörner, Andreas Pfnür, Joana E Ochoa, Deborah J Schächtele, Zahra Barabadi, Lea M Lang, Sudesh Srivastav, Matthew E Burow, Bysani Chandrasekar and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Rab27: Molecular switch of tumor exosome secretion (Review).International journal of molecular medicine · 2026
    Review
  2. Article
  3. Proteomic Exploration of L1CAMInternational journal of molecular sciences · 2025
    Article
  4. Inhibition of TRAF3IP2 Modulates NAMPT and NAD Metabolism in Glioblastoma.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Article
  5. Article
  6. Article
  7. [Silencing RAB27a inhibits proliferation, invasion and adhesion of triple-negative breast cancer cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Eckhard U Alt *Applied Stem Cell Laboratory, Department of Medicine, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Philipp M Wörner *Applied Stem Cell Laboratory, Department of Medicine, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Andreas PfnürApplied Stem Cell Laboratory, Department of Medicine, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Joana E OchoaDepartment of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Deborah J SchächteleApplied Stem Cell Laboratory, Department of Medicine, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Zahra BarabadiApplied Stem Cell Laboratory, Department of Medicine, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Lea M LangApplied Stem Cell Laboratory, Department of Medicine, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Sudesh SrivastavDepartment of Global Biostatistics and Data Science, Tulane University School of Public Health & Tropical Medicine, New Orleans, Louisiana, USA.
Matthew E BurowDepartment of Medicine, Section of Hematology & Medical Oncology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Bysani ChandrasekarDepartment of Medicine, University of Missouri School of Medicine and Harry S. Truman Veterans Memorial Hospital, Columbia, Missouri, USA.
Reza IzadpanahApplied Stem Cell Laboratory, Department of Medicine, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana, USA. rizadpan@tulane.edu.
Tulane University · USHarry S. Truman Memorial Veterans' Hospital · US

Funding

BLRD VA I01 BX004220BLRD VA IK6 BX004016
6 · The paper itself

Abstract

Here we investigated the roles of Rab27a, a player in exosome release, and TRAF3IP2, an inflammatory mediator, in development and metastasis of breast cancer (BC) in vivo. Knockdown (KD) of Rab27a (MDA

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBreast NeoplasmsCell Line, TumorCoculture TechniquesCytokinesExosomesFemaleGene Expression RegulationHumansMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMiceMice, NudeNeoplasm Metastasisrab27 GTP-Binding ProteinsAdaptor Proteins, Signal TransducingCytokinesRAB27A protein, humanrab27 GTP-Binding ProteinsRNA, Small InterferingTRAF3IP2 protein, human

Identifiers

PMID32483202
PMCPMC7264196
OpenAlexW3031196387

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.