ReviewPediatric gastroenterology, hepatology & nutrition2020
Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome.
Review in Pediatric gastroenterology, hepatology & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06206616 (Liver Steatosis in Pediatric Celiac Disease Patients), which is not on this map. Cited by 136 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Liver Steatosis in Pediatric Celiac Disease Patients: Exploring the Epidemiological and Pathophysiological Features of an Underestimated Condition
Who cites it
136 citing papers in PubMed, 6 syntheses or guidelines pooled it, 276 citations in OpenAlex.
- Lipid Accumulation Product Index as a Marker of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.Endocrinology, diabetes & metabolism · 2025Pooled it
- Managing pediatric metabolic syndrome: a systematic review of current approaches.BMC pediatrics · 2025Pooled it
- Prevalence of metabolic syndrome and its components in Iran: an updated meta-analysis.BMC endocrine disorders · 2025Pooled it
- The Impact of Cornelian Cherry (Nutrients · 2024Pooled it
- Metabolic syndrome and survival of patients with hepatocellular carcinoma: A meta-analysis.Frontiers in oncology · 2023Pooled it
- The relationship between metabolic syndrome and its components with bladder cancer: a systematic review and meta-analysis of cohort studies.Epidemiology and health · 2022Pooled it
- Lifestyle Intervention for Sustained Remission of Metabolic Syndrome: A Randomized Clinical Trial.JAMA internal medicine · 2026Trial
- Effectiveness of a canteen-based dietary intervention for metabolic syndrome in occupational men: A randomized controlled trial.Asia Pacific journal of clinical nutrition · 2025Trial
- Effect of an educational intervention using the extended parallel process model on preventive lifestyle for metabolic syndrome among Iranian employees.Scientific reports · 2025Trial
- Perceived Neighborhood Trust, Health Behaviors, and Metabolic Syndrome Among Middle-Aged and Older Chinese Adults: A Cross-Sectional Study.Behavioral sciences (Basel, Switzerland) · 2026Article
- Muscle Ultrasound Echo Intensity Detects Insulin Resistance Before Changes in HbAJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Association of HIF1α, BNIP3, and BNIP3L with Hypoxia-Related Metabolic Stress in Metabolic Syndrome.Medicina (Kaunas, Lithuania) · 2026Article
- Effectiveness of silymarin with lifestyle intervention in NAFLD and metabolic syndrome: a prospective single-arm study.Drugs in context · 2026Article
- The association between dietary protein intake and metabolic syndrome: a GRADE-assessed systematic review and meta-analysis of observational studies.Diabetology & metabolic syndrome · 2025Review
- Article
- Implications of pubertal stage in cardiometabolic risk factors in obese adolescents: a network analysis.BMC pediatrics · 2025Article
- Food Insecurity Associated With Higher Odds of Hypertriglyceridemic Waist Phenotype in Women: A Cross-Sectional Study.Food science & nutrition · 2025Article
- Metabolic syndrome in perimenopausal and postmenopausal women attending gynaecology outpatient department at a tertiary institution in South Africa.AJOG global reports · 2025Article
- Mean platelet volume as a biomarker of anemia and platelet disorders among metabolic syndrome patients in Northwest Ethiopia.Scientific reports · 2025Article
- Association of anthropometry indices and metabolic syndrome in Iranians: a cross-sectional study of the Fasa adult cohort study.BMJ open · 2025Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
The metabolic syndrome, by definition, is not a disease but is a clustering of individual metabolic risk factors including abdominal obesity, hyperglycemia, hypertriglyceridemia, hypertension, and low high-density lipoprotein cholesterol levels. These risk factors could dramatically increase the prevalence of type 2 diabetes and cardiovascular disease. The reported prevalence of the metabolic syndrome varies, greatly depending on the definition used, gender, age, socioeconomic status, and the ethnic background of study cohorts. Clinical and epidemiological studies have clearly demonstrated that the metabolic syndrome starts with central obesity. Because the prevalence of obesity has doubly increased worldwide over the past 30 years, the prevalence of the metabolic syndrome has markedly boosted in parallel. Therefore, obesity has been recognized as the leading cause for the metabolic syndrome since it is strongly associated with all metabolic risk factors. High prevalence of the metabolic syndrome is not unique to the USA and Europe and it is also increasing in most Asian countries. Insulin resistance has elucidated most, if not all, of the pathophysiology of the metabolic syndrome because it contributes to hyperglycemia. Furthermore, a major contributor to the development of insulin resistance is an overabundance of circulating fatty acids. Plasma fatty acids are derived mainly from the triglycerides stored in adipose tissues, which are released through the action of the cyclic AMP-dependent enzyme, hormone sensitive lipase. This review summarizes the latest concepts in the definition, pathogenesis, pathophysiology, and diagnosis of the metabolic syndrome, as well as its preventive measures and therapeutic strategies in children and adolescents.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.