ReviewInternational journal of molecular sciences2020
Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Integrated nutrient and plant growth regulator management improves cadmium phytoextraction in Ricinus communis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Potential Use of Grape Pomace for the Development of New Products: Study of Inorganic Elements Through Simulated Gastrointestinal Digestion.Foods (Basel, Switzerland) · 2026Article
- Circulating multiple metals and mortality after myocardial infarction: incremental value beyond GRACE.American journal of preventive cardiology · 2026Article
- Association of Multiple Plasma Metals With Cerebral Microbleeds: A Brain Magnetic Resonance Imaging-Based Study.Journal of the American Heart Association · 2026Article
- Rice bran extract ameliorates metal mixture induced cerebral cortex dysfunction: implicating the Nrf-2/HMOX-1/BDNF signalling pathway.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Dietary paeonol addition relieves the detrimental effect of waterborne cadmium on fish growth and liver health in largemouth bass (Micropterus salmoides).Fish physiology and biochemistry · 2026Article
- Effects of Micronutrients and Heavy Metals on Endothelial Function and Cardiovascular Risk in the Face of Environmental Changes.Current issues in molecular biology · 2025Review
- Exposure to Cadmium and Cerebrovascular Mortality in the United States.Hygiene and environmental health advances · 2025Article
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Causal association between cerebral small vessel disease and epilepsy.Neurosurgical review · 2025Article
- Cerebrovascular accident and essential and toxic metals: cluster analysis and principal component analysis.BMC pharmacology & toxicology · 2025Article
- Cerebrovascular accidents association between serum trace elements and toxic metals level, a case-control study.PloS one · 2025Article
- A Review of Potentially Toxic Elements in Sediment, Water, and Aquatic Species from the River Ecosystems.Toxics · 2024Review
- Associations of exposure to blood heavy metal mixtures withFrontiers in public health · 2024Article
- The Association among Urinary Lead and Cadmium, Serum Adiponectin, and Serum Apoptotic Microparticles in a Young Taiwanese Population.Nutrients · 2023Article
- Occupational Risk Factors for Stroke: A Comprehensive Review.Journal of stroke · 2023Review
- Tocotrienol-Rich Fraction Ameliorates the Aluminium Chloride-Induced Neurovascular Dysfunction-Associated Vascular Dementia in Rats.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke.Nutrients · 2023Article
- Inorganic Contaminants in Plant-Based Yogurts Commercialized in Brazil.International journal of environmental research and public health · 2023Article
- The Emerging Role of Autophagy as a Target of Environmental Pollutants: An Update on Mechanisms.Toxics · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heavy metals are considered a continuous threat to humanity, as they cannot be eradicated. Prolonged exposure to heavy metals/metalloids in humans has been associated with several health risks, including neurodegeneration, vascular dysfunction, metabolic disorders, cancer, etc. Small blood vessels are highly vulnerable to heavy metals as they are directly exposed to the blood circulatory system, which has comparatively higher concentration of heavy metals than other organs. Cerebral small vessel disease (CSVD) is an umbrella term used to describe various pathological processes that affect the cerebral small blood vessels and is accepted as a primary contributor in associated disorders, such as dementia, cognitive disabilities, mood disorder, and ischemic, as well as a hemorrhagic stroke. In this review, we discuss the possible implication of heavy metals/metalloid exposure in CSVD and its associated disorders based on in-vitro, preclinical, and clinical evidences. We briefly discuss the CSVD, prevalence, epidemiology, and risk factors for development such as genetic, traditional, and environmental factors. Toxic effects of specific heavy metal/metalloid intoxication (As, Cd, Pb, Hg, and Cu) in the small vessel associated endothelium and vascular dysfunction too have been reviewed. An attempt has been made to highlight the possible molecular mechanism involved in the pathophysiology, such as oxidative stress, inflammatory pathway, matrix metalloproteinases (MMPs) expression, and amyloid angiopathy in the CSVD and related disorders. Finally, we discussed the role of cellular antioxidant defense enzymes to neutralize the toxic effect, and also highlighted the potential reversal strategies to combat heavy metal-induced vascular changes. In conclusion, heavy metals in small vessels are strongly associated with the development as well as the progression of CSVD. Chelation therapy may be an effective strategy to reduce the toxic metal load and the associated complications.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.