Evidence map›Paper›PMID 32485850›Full record

ArticleInternational journal of molecular sciences2020

Transglutaminase 2 Has Metabolic and Vascular Regulatory Functions Revealed by In Vivo Activation of Alpha1-Adrenergic Receptor.

Kinga Lénárt, Attila Pap, Róbert Pórszász, Anna V Oláh, László Fésüs, András Mádi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Current Developments on the Role of αFrontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kinga LénártDepartment of Biochemistry and Molecular Biology, University of Debrecen, H-4032 Debrecen, Hungary.
Attila PapDepartment of Biochemistry and Molecular Biology, University of Debrecen, H-4032 Debrecen, Hungary.
Róbert PórszászDepartment of Pharmacology and Pharmacotherapy, University of Debrecen, H-4032 Debrecen, Hungary.
Anna V OláhDepartment of Laboratory Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
László FésüsDepartment of Biochemistry and Molecular Biology, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-3338-2362
András MádiDepartment of Biochemistry and Molecular Biology, University of Debrecen, H-4032 Debrecen, Hungary.
University of Debrecen · HU

Funding

Hungarian Economic Development and Innovation Operational Program GINOP-2.3.2-15-2016-00006Hungarian Science Research Fund OTKA K105046 and NKFIH K 129039New National Excellence Program of the Ministry for Innovation and Technology ÚNKP-19-3
6 · The paper itself

Abstract

The multifunctional tissue transglutaminase has been demonstrated to act as α1-adrenergic receptor-coupled G protein with GTPase activity in several cell types. To explore further the pathophysiological significance of this function we investigated the in vivo effects of the α1-adrenergic receptor agonist phenylephrine comparing responses in wild type and TG2

Indexed as

VasoconstrictionAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-1 Receptor AntagonistsAnimalsBlood VesselsDioxolesFatty AcidsGlucoseGTP-Binding ProteinsKidneyLiverL-Lactate DehydrogenaseLungMaleMiceMice, Inbred C57BLAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-1 Receptor AntagonistsDioxolesdisodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylateFatty AcidsGlucoseGTP-Binding ProteinsL-Lactate DehydrogenasePhenylephrineProtein Glutamine gamma Glutamyltransferase 2Receptors, Adrenergic, alpha-1Transglutaminasesblood pressureCLAMScreatine kinase MBheart failurelactate dehydrogenaserespiratory exchange ratiotransglutaminase 2 KO

Identifiers

PMID32485850
PMCPMC7312910
OpenAlexW3032435602

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.