Evidence map›Paper›PMID 32486044›Full record

ArticleDiagnostics (Basel, Switzerland)2020

David Moreno-Ajona, Elena Prieto, Fabiana Grisanti, Inés Esparragosa, Lizeth Sánchez Orduz, Jaime Gállego Pérez-Larraya, Javier Arbizu, Mario Riverol

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Autoimmune Encephalitis in Acute Care-Pathology, Diagnosis, and Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Article
  5. 2-[Asia Oceania journal of nuclear medicine & biology · 2025
    Article
  6. Article
  7. Quantitative brainAnnals of clinical and translational neurology · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Autoimmune encephalitis and seizures, cerebrospinal fluid, imaging, and EEG findings: a case series.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  16. Article
  17. Decrease in the cortex/striatum metabolic ratio on [European journal of nuclear medicine and molecular imaging · 2022
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

David Moreno-AjonaDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008 Pamplona, Spain.ORCID 0000-0002-0366-5994
Elena PrietoDepartment of Nuclear Medicine, Clínica Universidad de Navarra, Pío XII 36, 31008 Pamplona, Spain.ORCID 0000-0002-3609-1210
Fabiana GrisantiDepartment of Nuclear Medicine, Clínica Universidad de Navarra, Pío XII 36, 31008 Pamplona, Spain.ORCID 0000-0003-2626-5034
Inés EsparragosaDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008 Pamplona, Spain.
Lizeth Sánchez OrduzDepartment of Nuclear Medicine, Clínica Universidad de Navarra, Pío XII 36, 31008 Pamplona, Spain.
Jaime Gállego Pérez-LarrayaDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008 Pamplona, Spain.
Javier ArbizuDepartment of Nuclear Medicine, Clínica Universidad de Navarra, Pío XII 36, 31008 Pamplona, Spain.ORCID 0000-0002-8370-5510
Mario RiverolDepartment of Neurology, Clínica Universidad de Navarra, Pío XII 36, 31008 Pamplona, Spain.
Clinica Universidad de Navarra · ESUniversidad Autónoma de Bucaramanga · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain positron emission tomography imaging with 18Fluorine-fluorodeoxyglucose (FDG-PET) has demonstrated utility in suspected autoimmune encephalitis. Visual and/or assisted image reading is not well established to evaluate hypometabolism/hypermetabolism. We retrospectively evaluated patients with autoimmune encephalitis between 2003 and 2018. Patients underwent EEG, brain magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) sampling and autoantibodies testing. Individual FDG-PET images were evaluated by standard visual reading and assisted by voxel-based analyses, compared to a normal database. For the latter, three different methods were performed: two based on statistical surface projections (Siemens syngo.via Database Comparison, and 3D-SSP Neurostat) and one based on statistical parametric mapping (SPM12). Hypometabolic and hypermetabolic findings were grouped to identify specific patterns. We found six cases with definite diagnosis of autoimmune encephalitis. Two cases had anti-LGI1, one had anti-NMDA-R and two anti-CASPR2 antibodies, and one was seronegative.

Indexed as

18F-FDG-PETassisted analysisautoimmune encephalitislimbic encephalitisvoxel-based analysis

Identifiers

PMID32486044
PMCPMC7344773
OpenAlexW3028670566

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.