Evidence map›Paper›PMID 32489526›Full record

ArticleComputational and structural biotechnology journal2020

Guizhi Fuling Decoction inhibiting the PI3K and MAPK pathways in breast cancer cells revealed by HTS

Yifei Dai, Weijie Qiang, Xiankuo Yu, Siwei Cai, Kequan Lin, Lan Xie, Xun Lan, Dong Wang

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
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  7. A universal gene expression signature-based strategy for the high-throughput discovery of anti-inflammatory drugs.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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  13. Qingrexiaoji Recipe Regulates the Differentiation of M2 TAMCombinatorial chemistry & high throughput screening · 2024
    Article
  14. Review
  15. Article
  16. Traditional Chinese Medicine for Breast Cancer: A Review.Breast cancer (Dove Medical Press) · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Taohong Siwu Decoction exerts anticancer effects on breast cancer via regulatingComputational and structural biotechnology journal · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yifei DaiDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Weijie QiangInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Xiankuo YuSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Siwei CaiDepartment of Electronic and Computer Engineering, College of Engineering, Drexel University, Philadelphia 19104, USA.
Kequan LinSchool of Life Sciences, Tsinghua University, Beijing 100084, China.
Lan XieMedical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China.
Xun LanDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
Dong WangSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Tsinghua University · CNChengdu University of Traditional Chinese Medicine · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNDrexel University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As one of the classical traditional Chinese medicine (TCM) prescriptions in treating gynecological tumors, Guizhi Fuling Decoction (GFD) has been used to treat breast cancer (BRCA). Nonetheless, the potential molecular mechanism remains unclear so far. Therefore, systems pharmacology was used in combination with high throughput sequencing-based high throughput screening (HTS

Indexed as

BioinformaticsBreast cancerGuizhi Fuling DecoctionHTS2 assaySystems pharmacology

Identifiers

PMID32489526
PMCPMC7260686
OpenAlexW3027906585

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.