Evidence map›Paper›PMID 32492705›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2020

Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults.

Benjamin J Ryan, Michael W Schleh, Cheehoon Ahn, Alison C Ludzki, Jenna B Gillen, Pallavi Varshney, Douglas W Van Pelt, Lisa M Pitchford, Thomas L Chenevert, Rachel A Gioscia-Ryan and 6 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07312344 (Exploring the Impact of Exercise-derived Extracellular Vesicle in Blood and Physical Fitness Data in Overweight/Obesity Individuals on Lymphangiogenesis), which is not on this map. Cited by 120 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 13 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07312344 narecruitingnot on this mapstarted 2025, after this paper: background citation

Exploring the Impact of Exercise-derived Extracellular Vesicle in Blood and Physical Fitness Data in Overweight/Obesity Individuals on Lymphangiogenesis

TypeinterventionalSponsorMahidol UniversityRan2025 to 2026Enrolled20ConditionsObesity & OverweightArmsHigh-intensity interval training exercise on treadmill
3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 13 syntheses or guidelines pooled it, 191 citations in OpenAlex.

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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Benjamin J RyanSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Michael W SchlehSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Cheehoon AhnSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Alison C LudzkiSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Jenna B GillenSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Pallavi VarshneySubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Douglas W Van PeltSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Lisa M PitchfordSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Thomas L ChenevertDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.
Rachel A Gioscia-RyanSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Suzette M HowtonSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Thomas RodeSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
Scott L HummelDivision of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Charles F BurantDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Jonathan P LittleSchool of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada.
Jeffrey F HorowitzSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan.
University of Michigan · USUniversity of British Columbia · CAUniversity of Toronto · CA

Funding

TRAINING PROGRAM IN ENDOCRINOLOGY AND METABOLISM.T32DK007245 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1986 to 2005
$1.4M
Pilot and Feasibility (P and F) ProgramP30DK089503 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$1.2M
CIHR 146190CIHR 338735NIDDK NIH HHS F32 DK117522NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK077966NIDDK NIH HHS T32 DK007245NIDDK NIH HHS U24 DK097153
6 · The paper itself

Abstract

objectiveWe compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on insulin sensitivity and other important metabolic adaptations in adults with obesity.

methodsThirty-one inactive adults with obesity (age: 31 ± 6 years; body mass index: 33 ± 3 kg/m2) completed 12 weeks (4 sessions/week) of either HIIT (10 × 1-minute at 90%HRmax, 1-minute active recovery; n = 16) or MICT (45 minutes at 70%HRmax; n = 15). To assess the direct effects of exercise independent of weight/fat loss, participants were required to maintain body mass.

resultsTraining increased peak oxygen uptake by ~10% in both HIIT and MICT (P < 0.0001), and body weight/fat mass were unchanged. Peripheral insulin sensitivity (hyperinsulinemic-euglycemic clamp) was ~20% greater the day after the final exercise session compared to pretraining (P < 0.01), with no difference between HIIT and MICT. When trained participants abstained from exercise for 4 days, insulin sensitivity returned to pretraining levels in both groups. HIIT and MICT also induced similar increases in abundance of many skeletal muscle proteins involved in mitochondrial respiration and lipid and carbohydrate metabolism. Training-induced alterations in muscle lipid profile were also similar between groups.

conclusionDespite large differences in training intensity and exercise time, 12 weeks of HIIT and MICT induce similar acute improvements in peripheral insulin sensitivity the day after exercise, and similar longer term metabolic adaptations in skeletal muscle in adults with obesity. These findings support the notion that the insulin-sensitizing effects of both HIIT and MICT are mediated by factors stemming from the most recent exercise session(s) rather than adaptations that accrue with training.

Indexed as

High-Intensity Interval TrainingAdaptation, PhysiologicalAdultExerciseFemaleHumansInsulinInsulin ResistanceMaleMuscle, SkeletalObesitySedentary BehaviorTreatment OutcomeYoung AdultInsulinexercise traininghigh-intensity interval trainingInsulin resistanceskeletal muscle

Identifiers

PMID32492705
PMCPMC7347288
OpenAlexW3030392822

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.