Evidence map›Paper›PMID 32492818›Full record

ArticleJournal of clinical medicine2020

P2Y12 Inhibitor Monotherapy with Clopidogrel Versus Ticagrelor in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.

Po-Wei Chen, Wen-Han Feng, Ming-Yun Ho, Chun-Hung Su, Sheng-Wei Huang, Chung-Wei Cheng, Hung-I Yeh, Ching-Pei Chen, Wei-Chun Huang, Ching-Chang Fang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Safety of Bivalirudin Combined with Ticagrelor in the Emergency PCI in Patients with Acute ST-Segment Elevation Myocardial Infarction.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Po-Wei ChenDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.ORCID 0000-0003-2300-0698
Wen-Han FengDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan.ORCID 0000-0002-1994-6205
Ming-Yun HoDepartment of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Chun-Hung SuDepartment of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Sheng-Wei HuangDepartment of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Chung-Wei ChengDepartment of Internal Medicine, MacKay Memorial Hospital, Taipei 104, Taiwan.
Hung-I YehDepartment of Internal Medicine, MacKay Memorial Hospital, Taipei 104, Taiwan.ORCID 0000-0003-3206-0908
Ching-Pei ChenDepartment of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.
Wei-Chun HuangDepartment of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
Ching-Chang FangDepartment of Internal Medicine, Tainan Municipal Hospital, Tainan 701, Taiwan.
Hui-Wen Lin Sheng-Hsiang LinDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
I-Chang HsiehDepartment of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Yi-Heng LiDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
National Cheng Kung University Hospital · TWChang Gung University · TWChung Shan Medical University Hospital · TWMackay Memorial Hospital · TWChanghua Christian Hospital · TWKaohsiung Medical University Chung-Ho Memorial Hospital · TWNational Yang Ming Chiao Tung University · TWTainan Municipal Hospital · TW

Funding

Kaohsiung Municipal Ta-Tung Hospital kmtth-107-003
6 · The paper itself

Abstract

backgroundP2Y12 inhibitor monotherapy is an alternative antiplatelet strategy in patients undergoing percutaneous coronary intervention (PCI). However, the ideal P2Y12 inhibitor for monotherapy is unclear. METHODS AND

resultsWe performed a multicenter, retrospective, observational study to compare the efficacy and safety of monotherapy with clopidogrel versus ticagrelor in patients with acute coronary syndrome (ACS) undergoing PCI. From 1 January 2014 to 31 December 2018, 610 patients with ACS who received P2Y12 monotherapy with either clopidogrel (

conclusionsAmong patients with ACS undergoing PCI who cannot complete course of dual antiplatelet therapy, a significantly lower risk of cardiovascular events was associated with ticagrelor monotherapy than with clopidogrel monotherapy. The major bleeding risk was similar in both the groups.

Indexed as

acute coronary syndromeclopidogrelP2Y12 inhibitor monotherapyticagrelor

Identifiers

PMID32492818
PMCPMC7355760
OpenAlexW3031282119

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.