Evidence map›Paper›PMID 32493699›Full record

ArticleMolecular cancer research : MCR2020

Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling.

Jin-Yih Low, W Nathaniel Brennen, Alan K Meeker, Elina Ikonen, Brian W Simons, Marikki Laiho

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Cavin-1 promotes M2 macrophages/microglia polarization via SOCS3.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  10. Review
  11. Review
  12. Article
  13. The Lipid Asset Is Unbalanced in Peripheral Nerve Sheath Tumors.International journal of molecular sciences · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jin-Yih LowDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
W Nathaniel BrennenDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-9807-7433
Alan K MeekerDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Elina IkonenFaculty of Medicine, Anatomy and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Brian W SimonsCenter for Comparative Medicine, Baylor College of Medicine, Houston, Texas.
Marikki LaihoDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. mlaiho1@jhmi.edu.
Johns Hopkins University · USBaylor College of Medicine · USUniversity of Helsinki · FI

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

Lipid uptake occurs through caveolae, plasma membrane invaginations formed by caveolins (CAV) and caveolae-associated protein 1 (CAVIN1). Genetic alterations of

Indexed as

HumansInflammationLipid MetabolismMaleNeoplasm MetastasisProstatic NeoplasmsRNA-Binding ProteinsSignal TransductionTumor MicroenvironmentCAVIN1 protein, humanRNA-Binding Proteins

Identifiers

PMID32493699
PMCPMC8744066
OpenAlexW3030956731

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.