SynthesisJournal of the American Society of Nephrology : JASN2020
GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts.
Synthesis in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).The Cochrane database of systematic reviews · 2025Pooled it
- Pooled it
- Pooled it
- A Polyphenol-Rich Diet Increases the Gut Microbiota Metabolite Indole 3-Propionic Acid in Older Adults with Preserved Kidney Function.Molecular nutrition & food research · 2022Trial
- [The Nephrogeriatrics Research Network-achieving more through interdisciplinary approaches].Innere Medizin (Heidelberg, Germany) · 2026Review
- MERWACS: Development and external validation of a non-invasive machine learning tool for identifying subjects to be screened for CKD.PLOS digital health · 2026Article
- Keller/eGFR ratio as a simple and useful tool to make a first differentiation between renal aging and chronic nephropathy in large populations.International urology and nephrology · 2026Review
- Incident Hypertension in Young Adults With a Mild Estimated Glomerular Filtration Rate Reduction.Journal of the American Heart Association · 2026Article
- The aging-related GFR decline in Chinese healthy elderly.International urology and nephrology · 2026Article
- Polygenic Risk Scores Predicting Estimated GFR Validated With Iohexol Clearance.Kidney international reports · 2026Article
- Prevalence of reduced eGFR in European adults using KDIGO and age-adapted eGFR thresholds.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- When equations disagree: the impact of creatinine-based eGFR in CKD diagnosis and reclassification.BMC nephrology · 2025Article
- The Retinal Vasculature and Risk of Age-Related GFR Decline - The Renal Iohexol Clearance Survey.Kidney international reports · 2025Article
- Glomerular filtration rate and comorbidity factors in elderly hospitalizations.World journal of nephrology · 2025Article
- Disparities in chronic kidney disease burden estimates: From different sources, definitions, and equations.PloS one · 2025Article
- Independent and joint impacts of high body mass index and aging on global burden of chronic kidney disease: insights from the Global Burden of Disease Study 2021.Frontiers in nutrition · 2025Article
- Urinary Dickkopf-3 as a Potential Marker for Estimated Glomerular Filtration Rate Decline in Patients With Heart Failure.Journal of the American Heart Association · 2024Article
- IMPACT CKD: Holistic Disease Model Projecting 10-Year Population Burdens.Kidney international reports · 2024Article
- Unfortunate Terminology.Deutsches Arzteblatt international · 2024Article
- Cystatin C and the misdiagnosis of CKD in older adults.Nature reviews. Nephrology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundPopulation mean GFR is lower in older age, but it is unknown whether healthy aging is associated with preserved rather than lower GFR in some individuals.
methodsWe investigated the cross-sectional association between measured GFR, age, and health in persons aged 50-97 years in the general population through a meta-analysis of iohexol clearance measurements in three large European population-based cohorts. We defined a healthy person as having no major chronic disease or risk factors for CKD and all others as unhealthy. We used a generalized additive model to study GFR distribution by age according to health status.
resultsThere were 935 (22%) GFR measurements in persons who were healthy and 3274 (78%) in persons who were unhealthy. The mean GFR was lower in older age by -0.72 ml/min per 1.73 m
conclusionsHealthy aging is associated with a higher mean GFR compared with unhealthy aging. However, both the mean and 97.5 percentiles of the GFR distribution are lower in older persons who are healthy than in middle-aged persons who are healthy. This suggests that healthy aging is not associated with preserved GFR in old age.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.