Evidence map›Paper›PMID 32499508›Full record

ArticleNature communications2020

SIRT1 accelerates the progression of activity-based anorexia.

Timothy M Robinette, Justin W Nicholatos, Adam B Francisco, Kayla E Brooks, Rachel Y Diao, Sandro Sorbi, Valdo Ricca, Benedetta Nacmias, Miguel A Brieño-Enríquez, Sergiy Libert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Timothy M RobinetteDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.ORCID http://orcid.org/0000-0001-9050-2327
Justin W NicholatosDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Adam B FranciscoDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.ORCID http://orcid.org/0000-0001-8462-6569
Kayla E BrooksDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Rachel Y DiaoDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA.
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, 50139, Italy.
Valdo RiccaDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, 50139, Italy.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, 50139, Italy.ORCID http://orcid.org/0000-0001-9338-9040
Miguel A Brieño-EnríquezDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Sergiy LibertDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA. libert@calicolabs.com.ORCID http://orcid.org/0000-0003-2497-5390
Cornell University · USUniversity of Florence · ITUniversity of Pittsburgh · USDon Carlo Gnocchi Foundation · IT

Funding

NICHD NIH HHS K99 HD090289NICHD NIH HHS R00 HD090289
6 · The paper itself

Abstract

Food consumption is fundamental for life, and eating disorders often result in devastating or life-threatening conditions. Anorexia nervosa (AN) is characterized by a persistent restriction of energy intake, leading to lowered body weight, constant fear of gaining weight, and psychological disturbances of body perception. Herein, we demonstrate that SIRT1 inhibition, both genetically and pharmacologically, delays the onset and progression of AN behaviors in activity-based anorexia (ABA) models, while SIRT1 activation accelerates ABA phenotypes. Mechanistically, we suggest that SIRT1 promotes progression of ABA, in part through its interaction with NRF1, leading to suppression of a NMDA receptor subunit Grin2A. Our results suggest that AN may arise from pathological positive feedback loops: voluntary food restriction activates SIRT1, promoting anxiety, hyperactivity, and addiction to starvation, exacerbating the dieting and exercising, thus further activating SIRT1. We propose SIRT1 inhibition can break this cycle and provide a potential therapy for individuals suffering from AN.

Indexed as

Gene Expression RegulationAnimalsAnorexia NervosaBody WeightCarbazolesDisease Models, AnimalFemaleHeterocyclic Compounds, 4 or More RingsMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNuclear Respiratory Factor 1PhenotypeReceptors, N-Methyl-D-Aspartate6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamideCarbazolesGprin1 protein, mouseHeterocyclic Compounds, 4 or More RingsNerve Tissue ProteinsNrf1 protein, mouseNuclear Respiratory Factor 1Receptors, N-Methyl-D-AspartateResveratrolSirt1 protein, mouseSirtuin 1SRT1720

Identifiers

PMID32499508
PMCPMC7272424
OpenAlexW3033631746

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.