ArticleBMC psychiatry2020
Relationships between abnormal neural activities and cognitive impairments in patients with drug-naive first-episode schizophrenia.
Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Effects of multitask training on cognition and motor control in people with schizophrenia spectrum disorders.PloS one · 2022Trial
- Disrupted cortical organization in schizophrenia based on functional connectivity gradients.European archives of psychiatry and clinical neuroscience · 2026Article
- Orbitofrontal functional network: the mediating role between violence and childhood trauma in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Abnormal eye movement, brain regional homogeneity in schizophrenia and clinical high-risk individuals and their associated gene expression profiles.Schizophrenia (Heidelberg, Germany) · 2025Article
- Advances in MRI Research for First-Episode Schizophrenia: A Selective Review and NSFC-Funded Analysis.Schizophrenia bulletin · 2025Review
- Altered temporal lobe connectivity is associated with psychotic symptoms in drug-naïve adolescent patients with first-episode schizophrenia.European child & adolescent psychiatry · 2025Article
- Altered language-salience network connectivity in schizophrenia and differential associations with emotion regulation.Frontiers in psychiatry · 2025Article
- Use of the Chinese version of the MATRICS Consensus Cognitive Battery to assess cognitive functioning in individuals with high risk for psychosis, first-episode schizophrenia and chronic schizophrenia: a systematic review and meta-analysis.The Lancet regional health. Western Pacific · 2024Review
- Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia.Frontiers in psychiatry · 2024Article
- The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia.Journal of psychopharmacology (Oxford, England) · 2023Article
- Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A Longitudinal Resting-State fMRI Study.Schizophrenia bulletin · 2023Article
- Resting-state brain functional alterations and their genetic mechanisms in drug-naive first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Deviant spontaneous neural activity as a potential early-response predictor for therapeutic interventions in patients with schizophrenia.Frontiers in neuroscience · 2023Article
- Neuroimaging biomarkers for detecting schizophrenia: A resting-state functional MRI-based radiomics analysis.Heliyon · 2022Article
- Disrupted local functional connectivity in schizophrenia: An updated and extended meta-analysis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.Schizophrenia (Heidelberg, Germany) · 2022Review
- Alterations in Spontaneous Brain Activity in Drug-Naïve First-Episode Schizophrenia: An Anatomical/Activation Likelihood Estimation Meta-Analysis.Psychiatry investigation · 2022Article
- Aberrant cortical surface and cognition function in drug-naive first-episode schizophrenia.Annals of general psychiatry · 2022Article
- Altered brain activity in the bilateral frontal cortices and neural correlation with cognitive impairment in schizophrenia.Brain imaging and behavior · 2022Article
- Abnormal patterns of regional homogeneity and functional connectivity across the adolescent first-episode, adult first-episode and adult chronic schizophrenia.NeuroImage. Clinical · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPrior resting state functional Magnetic Resonance Imaging studies (rs-fMRI) via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, and illness duration. Relationships between ReHo measures and cognitive impairments in patients with drug-naive First-Episode Schizophrenia (dn-FES) are rarely reported. This study was conducted to explore the correlations between ReHo measures and cognitive deficits and clinical symptoms in patients with dn-FES.
methodsA total of 69 patients with dn-FES and 74 healthy controls were recruited. MATRICS Consensus Cognitive Battery (MCCB), Wechsler Adult Intelligence Scale (WAIS), and Positive And Negative Syndrome Scale (PANSS) were used to assess cognitive function, Intelligence Quotient (IQ), and clinical symptoms, respectively. The correlations between ReHo maps and cognitive deficits and the severity of symptoms were examined using strict correlation analysis.
resultsReHo values in right Middle Frontal Gyrus (MFG) and Superior Frontal Gyrus (SFG) increased in dn-FES group, whereas ReHo values in right cuneus decreased. Correlation analysis showed that the ReHo values in right MFG positively correlated with attention/vigilance impairments, social cognition deficits, and the severity of clinical manifestations.
conclusionsThese findings suggested that abnormal spontaneous activities in right MFG reflect illness severity and cognitive deficits, which also serve as a basis for establishing objective diagnostic markers and might be a clinical intervention target for treating patients with schizophrenia.
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