ArticleJournal of clinical laboratory analysis2020
Comparison of four matrixes for diluting insulin in routine clinical measurements.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Measurement comparability of insulin assays using conventional immunoassay kits.Journal of clinical laboratory analysis · 2022Article
- Comparison of four matrixes for diluting insulin in routine clinical measurements.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIn our laboratory, 2.36% (6626/280765) samples obtained for insulin evaluation have serum insulin concentrations higher than 300 mU/L, resulting in curves outside the linear range in the insulin release test (IRT). Accordingly, using appropriate dilution protocols to determine insulin concentration accurately is important. Here, we compared the effectiveness and economy of four different solutions for diluting high-insulin serum in routine clinical measurements.
methodResidual serum samples with high-insulin concentrations ranging from 200 to 300 mU/L were collected in Peking Union Medical College Hospital from August to November 2017. Four different matrixes including a Siemens original diluent, pure water, 0.9% NaCl, and low-insulin serum (labeled as A to D, respectively) were used to dilute the serum in the ratios of 1:2, 1:5, and 1:10.
resultsWe found that the linear correlation coefficients of A to D were higher than 0.9. The recovery rates of A to D were 86.4%-104.0%, 73.2%-99.3%, 76.4%-101.3%, and 84.2%-99.7%, respectively. We conclude that the use of 0.9% NaCl, pure water, or low-insulin serum to dilute high-serum insulin (>300 mU/L) is feasible and cost-effective.
conclusionWe recommend a dilution factor of 1:5 on a Siemens ADVIA Centaur XP
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Registered trials
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