ReviewAmerican journal of cancer research2020
Breast cancer in low-middle income countries: abnormality in splicing and lack of targeted treatment options.
Review in American journal of cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Breast cancer survival rates and determinants in Ethiopia: a systematic review and meta-analysis of longitudinal studies.BMC cancer · 2025Pooled it
- Breast cancer survival in Ethiopia: a systematic review and meta-analysis of rates and predictors.Cancer causes & control : CCC · 2025Pooled it
- Barriers to cervical cancer and breast cancer screening uptake in low- and middle-income countries: a systematic review.Health policy and planning · 2023Pooled it
- Factors Affecting Delayed Presentation and Diagnosis of Breast Cancer in Asian Developing Countries Women: A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2021Pooled it
- Breast Nurse Intervention to Improve Adherence to Endocrine Therapy Among Breast Cancer Patients in South Ethiopia.The oncologist · 2022Trial
- Knowledge of early signs and risk factors, and attitude towards breast cancer among women in Dodoma, Tanzania: a community-based cross-sectional study.Future science OA · 2026Article
- The Impact of Diabetes on Breast Cancer Development in Women: An Integrative Review.Endocrinology, diabetes & metabolism · 2026Review
- Exploring the Role ofHealth science reports · 2026Article
- Article
- Patient-Reported Quality of Life Predicts First-Cycle Pharmacotherapy Survival in Breast Cancer: A Prospective Cohort Study.Medical sciences (Basel, Switzerland) · 2026Article
- Clinical outcomes of synthetic absorbable mesh use in breast surgery: First case series in reconstruction and aesthetic mastopexy.JPRAS open · 2026Article
- Partnership Driving Impact: An Integrated Women-Centric Model to Improve Early Detection and Treatment of Cervical and Breast Cancer in Ghana and India.Cancer medicine · 2026Article
- Total treatment interval and quality of life of women living with breast cancer in Ethiopia: the mediating role of financial toxicity.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Subtherapeutic exposure in doxorubicin pharmacokinetics among Ugandan breast cancer patients: a pilot study with implications for personalized therapy.BMC research notes · 2026Article
- Development and validation of an 11-CpG methylation signature-based nomogram for predicting prognosis in early-onset breast cancer.Translational cancer research · 2026Article
- Targeted Protein Degradation in Cancer: PROTACs, New Targets, and Clinical Mechanisms.Biomolecules · 2026Review
- Comparative spectral analysis of blood and saliva in breast cancer, benign breast disease and healthy controls using ATR-FTIR.Scientific reports · 2026Article
- Pharmacophore modeling and molecular dynamics simulations to study the conformational stability of natural HER2 inhibitors in breast cancer therapy.Molecular diversity · 2026Article
- Barriers and interventions to improve the uptake of cancer risk management strategies in hereditary cancer syndromes: a narrative review.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2026Review
- Age-Related Trends in Breast Cancer Incidence.International journal of breast cancer · 2026Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is a common malignancy among women worldwide. Regardless of the economic status of a country, breast cancer poses a burden in prevention, diagnosis and treatment. Developed countries such as the U.S. have high incidence and mortality rates of breast cancer. Although low incidence rates are observed in developing countries, the mortality rate is on the rise implying that low- to middle-income countries lack the resources for preventative screening for early detection and adequate treatment resources. The differences in incidence between countries can be attributed to changes in exposure to environmental risk factors, behaviour and lifestyle factors of the different population groups. Genomic modifications are an important factor that significantly alters the risk profile of breast tumourigenesis. The incidence of early-onset breast cancer is increasing and evidence shows that early onset of breast cancer is far more aggressive than late onset of the disease; possibly due to the difference in genetic alterations or tumour biology. Alternative splicing is a pivotal factor in the progressions of breast cancer. It plays a significant role in tumour prognosis, survival and drug resistance; hence, it offers a valuable option as a therapeutic target. In this review, the differences in breast cancer incidence and mortality rates in developed countries will be compared to low- to middle-income countries. The review will also discuss environmental and lifestyle risk factors, and the underlying molecular mechanisms, genetic variations or mutations and alternative splicing that may contribute to the development and novel drug targets for breast cancer.
Indexed as
Identifiers
32509398PMC7269781What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.