ArticleEClinicalMedicine2020
Increased weight loading reduces body weight and body fat in obese subjects - A proof of concept randomized clinical trial.
Article in EClinicalMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Different Weight Vests on Body Weight in Obese Individuals
Effect of Artificial Loading, Through Application of Weight Vests, on Body Weight in Obese Subjects; a Randomized Controlled Trial
Effect of Weight Load on Bone Glucose Uptake in Obese Subjects
Effectiveness of the Use of External Body Weight in the Regulation of Body Weight, Body Composition and Analytical Parameters in Adults With Grade II and III Obesity
Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Short-term effects of weight-loading on heart rate variability in obese adults.Physiological reports · 2026Trial
- Trial
- Loading Enhances Glucose Uptake in Muscles, Bones, and Bone Marrow of Lower Extremities in Humans.The Journal of clinical endocrinology and metabolism · 2024Trial
- Sustainability of Hiking in Combination with Coaching in Cardiorespiratory Fitness and Quality of Life.International journal of environmental research and public health · 2022Trial
- Validity of energy expenditure from combined accelerometry and heart rate during load carriage in adults with overweight to mild obesity.European journal of applied physiology · 2026Article
- Telehealth Intervention to Reduce Sedentary Behavior in Older Adults With Type 2 Diabetes: Development and Feasibility Study.Journal of medical Internet research · 2026Article
- The effect of increased weight loading on body weight is partly dependent on Piezo1 in osteoblast-lineage cells and TrkA signaling.Scientific reports · 2026Article
- New Insight Into Male Infertility: Deviation From Basic Tenets of Life.Oxidative medicine and cellular longevity · 2026Review
- The role of bone in whole-body energy metabolism.Nature reviews. Endocrinology · 2025Review
- Increased weight-bearing load reduces biological body weight while sodium and water balances are unaffected.Pflugers Archiv : European journal of physiology · 2025Article
- Does weighted vest use during weight loss influence long-term weight loss maintenance? A pilot study in older adults living with obesity and osteoarthritis.International journal of obesity (2005) · 2025Article
- Machine learning applications in the analysis of sedentary behavior and associated health risks.Frontiers in artificial intelligence · 2025Review
- What is Balance? A Vital Mechano-Regulation Paradigm.Open mind : discoveries in cognitive science · 2025Article
- Association of sedentary behaviour with gout and the interaction effect of hyperuricemia: a cross-sectional study from 2007 to 2018.BMC public health · 2024Article
- Improved walking energy efficiency might persist in presence of simulated full weight regain after multidisciplinary weight loss in adolescents with obesity: the POWELL study.International journal of obesity (2005) · 2024Article
- Task-specific resistance training adaptations in older adults: comparing traditional and functional exercise interventions.Frontiers in aging · 2024Article
- The fructose survival hypothesis for obesity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Effects of war exposure on pubertal development in refugee children.Developmental psychology · 2023Article
- Energy Balance and Bone Health: a Nutrient Availability Perspective.Current osteoporosis reports · 2023Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently we provided evidence for a leptin-independent homeostatic regulation,
methodsWe conducted a randomized controlled single center trial (ClinicalTrial.gov number, NCT03672903), to evaluate the efficacy of artificially increased weight loading on body weight in subjects with mild obesity (BMI 30-35 kg/m
findingsIn total 72 participants underwent randomization and 69 (36 high load and 33 low load) completed the study for the primary outcome. High load treatment resulted in a more pronounced relative body weight loss compared to low load treatment (mean difference -1.37%, 95% confidence interval (CI), -1.96 to -0.79;
interpretationIncreased weight loading reduces body weight and fat mass in obese subjects in a similar way as previously shown in obese rodents. These findings demonstrate that there is weight loading dependent homeostatic regulation of body weight, the gravitostat, also in humans.
fundingFunded by Jane and Dan Olsson (JADO) Foundation, the Torsten Söderberg Foundation, The Knut and Alice Wallenberg's Foundation and the Novo Nordisk Foundation.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.