Evidence map›Paper›PMID 32510982›Full record

ArticleCirculation. Genomic and precision medicine2020

Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels.

Zhe Wang, Han Chen, Traci M Bartz, Lawrence F Bielak, Daniel I Chasman, Mary F Feitosa, Nora Franceschini, Xiuqing Guo, Elise Lim, Raymond Noordam and 31 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 18 institutions in 5 countries.

Zhe WangDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
Han ChenDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
Traci M BartzCardiovascular Health Research Unit, Department of Biostatistics and Medicine (T.M.B.), University of Washington, Seattle, WA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health (L.F.B., J.A.S., W.Z., S.L.R.K.), University of Michigan, Ann Arbor, MI.
Daniel I ChasmanDivision of Preventive Medicine (D.I.C., F.G.), Brigham and Women's Hospital, Boston, MA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO (M.F.F., M.A.P.).
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (N.F.).
Xiuqing GuoDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., J.I.R.).
Elise LimBiostatistics Department, Boston University School of Public Health, MA (E.L., L.A.C., C.-T.L.).
Raymond NoordamSection of Gerontology and Geriatrics, Department of Internal Medicine (R.N.), Leiden University Medical Center, the Netherlands.
Melissa A RichardBrown Foundation Institute of Molecular Medicine (M.A.R., M.F.), University of Texas Health Science Center at Houston, Houston, TX.
Heming WangDivision of Sleep and Circadian Disorders, Department of Medicine (H.W., B.C., J.L., S.R., P.M.R.), Brigham and Women's Hospital, Boston, MA.
Brian CadeDivision of Sleep and Circadian Disorders, Department of Medicine (H.W., B.C., J.L., S.R., P.M.R.), Brigham and Women's Hospital, Boston, MA.
L Adrienne CupplesBiostatistics Department, Boston University School of Public Health, MA (E.L., L.A.C., C.-T.L.).
Paul S de VriesDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
Franco GiulaniniDivision of Preventive Medicine (D.I.C., F.G.), Brigham and Women's Hospital, Boston, MA.
Jiwon LeeDivision of Sleep and Circadian Disorders, Department of Medicine (H.W., B.C., J.L., S.R., P.M.R.), Brigham and Women's Hospital, Boston, MA.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine (R.N.L., C.M.S.), University of Washington, Seattle, WA.
Lisa W MartinGeorge Washington University School of Medicine and Health Sciences, DC (L.W.M.).
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (A.P.R., C.K.).
Stephen S RichDepartment of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville (S.S.R.).
Pamela J SchreinerEpidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (P.J.S.).
Stephen SidneyDivision of Research, Kaiser Permanente Northern California, Oakland (S.S.).
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine (R.N.L., C.M.S.), University of Washington, Seattle, WA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health (L.F.B., J.A.S., W.Z., S.L.R.K.), University of Michigan, Ann Arbor, MI.
Ko Willems van DijkDepartment of Human Genetics (K.W.v.D.), Leiden University Medical Center, the Netherlands.
Jie YaoDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., J.I.R.).
Wei ZhaoDepartment of Epidemiology, School of Public Health (L.F.B., J.A.S., W.Z., S.L.R.K.), University of Michigan, Ann Arbor, MI.
Myriam FornageDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health (L.F.B., J.A.S., W.Z., S.L.R.K.), University of Michigan, Ann Arbor, MI.
Charles KooperbergDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
Ching-Ti LiuDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology (D.O.M.-K.), Leiden University Medical Center, the Netherlands.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO (M.F.F., M.A.P.).
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services (B.M.P.), University of Washington, Seattle, WA.
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine (H.W., B.C., J.L., S.R., P.M.R.), Brigham and Women's Hospital, Boston, MA.
Paul M RidkerDivision of Sleep and Circadian Disorders, Department of Medicine (H.W., B.C., J.L., S.R., P.M.R.), Brigham and Women's Hospital, Boston, MA.
Jerome I RotterDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., J.I.R.).
Eric BoerwinkleDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
CHARGE Gene-Lifestyle Interactions Working GroupDepartment of Epidemiology, Human Genetics Center, Human Genetics and Environmental Sciences, School of Public Health (Z.W., H.C., P.S.d.V., M.F., E.B., A.C.M.), University of Texas Health Science Center at Houston, Houston, TX.
Brigham and Women's Hospital · USThe University of Texas Health Science Center at Houston · USUniversity of Michigan · USLeiden University Medical Center · NLUCLA Medical Center · USUniversity of Washington · USBoston University · USBrown Foundation · USWashington University in St. Louis · USBaylor College of Medicine · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAGeorge Washington University · USKaiser Permanente · USKaiser Permanente Washington Health Research Institute · USOffice of Public Health Genomics · USThe University of Texas Health Science Center at Tyler · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · US

Funding

CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Leveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6M
Genetics of kidney disease in diverse populationsR01DK117445 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2018 to 2022
$2.7M
Genetic Mechanisms of Arteriosclerosis in Hypertensive SibshipsR01HL119443 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2014 to 2017
$2.1M
Whole Genomic Characterization of Sleep Apnea Traits and Comorbid DisordersK01HL135405 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CADE, BRIAN EDMAND · 2017 to 2020
$695k
Phenome-wide association of protein function-altering variants in a family studyR21HL140385 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2018
$229k
Identifying Contributions of Pulmonary Inflammation to Sleep-Disordered BreathingR03HL154284 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CADE, BRIAN EDMAND · 2020 to 2021
$179k
NHLBI NIH HHS K01 HL135405NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R03 HL154284NHLBI NIH HHS R21 HL140385NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIDDK NIH HHS R01 DK117445NIMHD NIH HHS R01 MD012765
6 · The paper itself

Abstract

backgroundAlcohol intake influences plasma lipid levels, and such effects may be moderated by genetic variants. We aimed to characterize the role of aggregated rare and low-frequency protein-coding variants in gene by alcohol consumption interactions associated with fasting plasma lipid levels.

methodsIn the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, fasting plasma triglycerides and high- and low-density lipoprotein cholesterol were measured in 34 153 individuals with European ancestry from 5 discovery studies and 32 277 individuals from 6 replication studies. Rare and low-frequency functional protein-coding variants (minor allele frequency, ≤5%) measured by an exome array were aggregated by genes and evaluated by a gene-environment interaction test and a joint test of genetic main and gene-environment interaction effects. Two dichotomous self-reported alcohol consumption variables, current drinker, defined as any recurrent drinking behavior, and regular drinker, defined as the subset of current drinkers who consume at least 2 drinks per week, were considered.

resultsWe discovered and replicated 21 gene-lipid associations at 13 known lipid loci through the joint test. Eight loci (

conclusionsIn conclusion, this study applied new gene-based statistical approaches and suggested that rare and low-frequency genetic variants interacted with alcohol consumption on lipid levels.

Indexed as

Genome-Wide Association StudyAdolescentAdultAgedAged, 80 and overAlcohol DrinkingApolipoproteins ECholesterol, HDLFemaleGene FrequencyGenetic LociHumansLipidsMaleMiddle AgedPolymorphism, Single NucleotideApolipoproteins ECholesterol, HDLLipidsPCSK9 protein, humanProprotein Convertase 9Triglyceridesexomegene-environment interactiongenome-wide association studylipidsself-report

Identifiers

PMID32510982
PMCPMC7442680
OpenAlexW3033303460

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.