Evidence map›Paper›PMID 32518242›Full record

ArticleScientific reports2020

Hesperidin Loaded on Gold Nanoparticles as a Drug Delivery System for a Successful Biocompatible, Anti-Cancer, Anti-Inflammatory and Phagocytosis Inducer Model.

Ghassan M Sulaiman, Hanaa M Waheeb, Majid S Jabir, Shaymaa H Khazaal, Yaser Hassan Dewir, Yougasphree Naidoo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 245 citations in OpenAlex.

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  15. Synthesis of metallic nanoparticles using biometabolites: mechanisms and applications.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Ghassan M SulaimanBiotechnology Division, Applied Science Department, University of Technology, Baghdad, Iraq. 100135@uotechnology.edu.iq.ORCID http://orcid.org/0000-0001-6388-3849
Hanaa M WaheebBiotechnology Division, Applied Science Department, University of Technology, Baghdad, Iraq.
Majid S JabirBiotechnology Division, Applied Science Department, University of Technology, Baghdad, Iraq.
Shaymaa H KhazaalApplied Chemistry Division, Applied Science Department, University of Technology, Baghdad, Iraq.
Yaser Hassan DewirKing Saud University, College of Food and Agriculture Sciences, P.O. Box 2460, Riyadh, 11451, Saudi Arabia.
Yougasphree NaidooUniversity of KwaZulu-Natal, School of Life Sciences, Westville Campus, Private Bag X54001, Durban, 4000, South Africa.
University of Technology - Iraq · IQKafrelsheikh University · EGUniversity of KwaZulu-Natal · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hesperidin is a flavonoid glycoside with proven therapeutic activities for various diseases, including cancer. However, its poor solubility and bioavailability render it only slightly absorbed, requiring a delivery system to reach its therapeutic target. Hesperidin loaded on gold nanoparticles (Hsp-AuNPs) was prepared by a chemical synthesis method. Various characterization techniques such as UV-VIS spectroscopy, FTIR, XRD, FESEM, TEM and EDX, Zeta potential analysis, particle size analysis, were used to confirm the synthesis of Hsp-AuNPs. The cytotoxic effect of Hsp-AuNPs on human breast cancer cell line (MDA-MB-231) was assessed using MTT and crystal violet assays. The results revealed significant decrease in proliferation and inhibition of growth of the treated cells when compared with human normal breast epithelial cell line (HBL-100). Determination of apoptosis by fluorescence microscope was also performed using acridine orange-propidium iodide dual staining assay. The in vivo study was designed to evaluate the toxicity of Hsp-AuNPs in mice. The levels of hepatic and kidney functionality markers were assessed. No significant statistical differences were found for the tested indicators. Histological images of liver, spleen, lung and kidney showed no apparent damages and histopathological abnormalities after treatment with Hsp-AuNPs. Hsp-AuNPs ameliorated the functional activity of macrophages against Ehrlich ascites tumor cells-bearing mice. The production of the pro-inflammatory cytokines was also assessed in bone marrow-derived macrophage cells treated with Hsp-AuNPs. The results obviously demonstrated that Hsp-AuNPs treatment significantly inhibited the secretion of IL-1β, IL-6 and TNF.

Indexed as

AnimalsAnti-Inflammatory AgentsAntineoplastic AgentsDrug CarriersDrug LiberationGoldHesperidinHumansMaleMaterials TestingMetal NanoparticlesMiceOxidative StressPhagocytosisAnti-Inflammatory AgentsAntineoplastic AgentsDrug CarriersGoldHesperidin

Identifiers

PMID32518242
PMCPMC7283242
OpenAlexW3033058121

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.