ArticlePain2020
Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations.
Article in Pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 90 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized-Controlled Trial of Semaglutide for Patients With Chronic Low Back Pain and Obesity
Examining Different Components of Online Acceptance and Commitment Therapy for Chronic Pain in a Sample of People With Chiari Malformation
A Modular Open Label, Signal Seeking, Phase II Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations (TARGET-VM)
Who cites it
90 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Esmolol as an Adjunct in Multimodal Anesthesia: A Systematic Review and Meta-Analysis of Its Opioid-Sparing and Analgesic Effects.Anesthesia and analgesia · 2026Pooled it
- Interventions to safely and effectively reduce (taper) use of opioids in chronic non-cancer pain: a systematic review.Health technology assessment (Winchester, England) · 2026Pooled it
- Comparative effectiveness of regional analgesia techniques after gastrectomy for gastric cancer: a systematic review and network meta-analysis of randomized trials.Frontiers in medicine · 2026Pooled it
- Nonpharmacological Interventions for Chronic Pain in Older Adults: A Systematic Review and Meta-Analysis.The Gerontologist · 2024Pooled it
- Thoracolumbar Interfascial Plane (TLIP) block verses other paraspinal fascial plane blocks and local infiltration for enhanced pain control after spine surgery: a systematic review.BMC anesthesiology · 2024Pooled it
- The effectiveness of intradiscal corticosteroid injection for the treatment of chronic discovertebral low back pain: a systematic review.Pain medicine (Malden, Mass.) · 2024Pooled it
- Intrathecal Drug Delivery Systems for Cancer Pain: A Health Technology Assessment.Ontario health technology assessment series · 2024Pooled it
- Peripheral Nerve Stimulation for Chronic Neuropathic Pain: A Health Technology Assessment.Ontario health technology assessment series · 2024Pooled it
- Psychological therapies for temporomandibular disorders (TMDs).The Cochrane database of systematic reviews · 2022Pooled it
- Multimethod quantitative benefit-risk assessment of treatments for moderate-to-severe osteoarthritis.British journal of clinical pharmacology · 2022Pooled it
- Pregabalin efficacy in painful diabetic peripheral neuropathy: A focused analysis of optimal dosing and the relationship of baseline glycemic control.Journal of diabetes investigation · 2026Trial
- 4-Week Comparative Outcomes of Standard Physiotherapy, Balneotherapy Plus Physiotherapy and Dextrose Prolotherapy in Patients with Low Back Pain: A Non-Randomized Study.Medicina (Kaunas, Lithuania) · 2026Trial
- Paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component in treatment of neuropathic pain after incomplete spinal cord injury - a pilot trial.Spinal cord series and cases · 2026Trial
- Transcutaneous Electrical Nerve Stimulation and Pain With Movement in People With Fibromyalgia: A Cluster Randomized Clinical Trial.JAMA network open · 2026Trial
- Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial.Nature medicine · 2025Trial
- Cyclic sighing in the clinic waiting room may decrease pain: results from a pilot randomized controlled trial.Journal of behavioral medicine · 2025Trial
- Estimating minimal important change of the National Institutes of health research task force impact score using computer adaptive measures: a secondary analysis of two randomized clinical trials in a military population with chronic pain.BMC musculoskeletal disorders · 2025Trial
- Pain Coping Skills Training for Patients Receiving Hemodialysis: The HOPE Consortium Randomized Clinical Trial.JAMA internal medicine · 2025Trial
- Intravenous Lidocaine for Refractory Pain in Patients With Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis: A Multicenter Prospective Nonrandomized Pilot Study.Clinical and translational gastroenterology · 2024Trial
- Is the Capsaicin 179 mg (8% w/w) Cutaneous Patch an Appropriate Treatment Option for Older Patients with Peripheral Neuropathic Pain?Journal of pain research · 2024Trial
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Funding
Abstract
Interpreting randomized clinical trials (RCTs) is crucial to making decisions regarding the use of analgesic treatments in clinical practice. In this article, we report on an Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) consensus meeting organized by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks, the purpose of which was to recommend approaches that facilitate interpretation of analgesic RCTs. We review issues to consider when drawing conclusions from RCTs, as well as common methods for reporting RCT results and the limitations of each method. These issues include the type of trial, study design, statistical analysis methods, magnitude of the estimated beneficial and harmful effects and associated precision, availability of alternative treatments and their benefit-risk profile, clinical importance of the change from baseline both within and between groups, presentation of the outcome data, and the limitations of the approaches used.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.