Evidence map›Paper›PMID 32523674›Full record

ArticleTherapeutic advances in endocrinology and metabolism2020

Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes.

Aleksandra Żebrowska, Marcin Sikora, Anna Konarska, Anna Zwierzchowska, Tomasz Kamiński, Anna Robins, Barbara Hall

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Aleksandra ŻebrowskaInstitute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikolowska Street 72 A, Katowice 40-065, Poland.ORCID https://orcid.org/0000-0001-7446-528X
Marcin SikoraDepartment of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
Anna KonarskaDepartment of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
Anna Zwierzchowska
Tomasz KamińskiDepartment of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
Anna RobinsSchool of Biological Sciences, Division of Infection, Immunity and Respiratory Medicine, University of Salford, Salford, UK.
Barbara HallSchool of Health Sciences, University of Salford, Salford, UK.
Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach · PLUniversity of Salford · GBAdvanced Neural Dynamics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aimed to determine the effect of moderate intensity continuous exercise (Ex) and hypoxia (Hyp) on serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3), irisin and cytokines levels in patients with type 1 diabetes (T1D).

methodsA total of 14 individuals with T1D (age: 28.7 ± 7.3 years) and 14 healthy adults (age: 27.1 ± 3.9 years) performed 40-min continuous Ex at moderate intensity (50% lactate threshold) on a cycle ergometer in normoxia (Nor) and Hyp (FiO

resultsPatients with T1D had significantly lower pre-Ex serum concentrations of BDNF (

conclusionThe study results suggest that moderate intensity continuous Ex has beneficial effect on BDNF and IGF-1 levels. Ex in hypoxic conditions may be more effective in increasing availability of IGF-1. The alterations in the post-Ex irisin levels and IGF-1 system may be contributing to more effective glycaemia control in patients with T1D.

Indexed as

diabetesexercisehypoxiamyokines

Identifiers

PMID32523674
PMCPMC7257872
OpenAlexW3029901145

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.