SynthesisMolecular neurobiology2020
Postmortem Studies of Neuroinflammation in Autism Spectrum Disorder: a Systematic Review.
Synthesis in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Bibliometric study of neuroinflammation in autism spectrum disorder.Frontiers in psychiatry · 2023Pooled it
- Therapeutic potential of edaravone and flurbiprofen in valproic acid-induced autism: Targeting oxidative stress and neuroinflammation.IBRO neuroscience reports · 2026Article
- Early-life oxidative stress programs persistent NFκB activation and neuroinflammation in autism spectrum disorder.Frontiers in immunology · 2026Article
- Research progress on the microbiota-gut-brain axis in autism spectrum disorder: a narrative review.Frontiers in microbiology · 2026Review
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- Electroacupuncture ameliorates Autism Spectrum Disorder via modulating the gut-brain axis depending on the integrity of vagus nerve.Translational psychiatry · 2025Article
- Redox System Dysfunction as a Key Mechanism in Autism Spectrum Disorder Pathogenesis.International journal of molecular sciences · 2025Review
- Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder.Brain, behavior, & immunity - health · 2025Review
- Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years.Molecular autism · 2025Article
- Intermittent Fasting Improves Social Interaction and Decreases Inflammatory Markers in Cortex and Hippocampus.Molecular neurobiology · 2025Article
- Immunological Biomarkers in Autism Spectrum Disorder: The Role of TNF-Alpha and Dependent Trends in Serum IL-6 and CXCL8.Life (Basel, Switzerland) · 2024Article
- Exploring the Missing link between vitamin D and autism spectrum disorder: Scientific evidence and new perspectives.Heliyon · 2024Article
- Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Comparison of serum thrombospondin-1 and thrombospondin-2 levels among children with autism spectrum disorder and healthy controls.International journal of developmental disabilities · 2024Article
- A most important gift: the critical role of postmortem brain tissue in autism science.Frontiers in neurology · 2024Article
- Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications.Medicinal research reviews · 2023Review
- A Disintegrin and Metalloproteinase Protein 8 (ADAM 8) in Autism Spectrum Disorder: Links to Neuroinflammation.Neuropsychiatric disease and treatment · 2023Article
- Pathology and Astrocytes in Autism.Neuropsychiatric disease and treatment · 2023Review
- Review
- Superoxide dismutase isozymes in cerebral organoids from autism spectrum disorder patients.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the neurobiological basis for autism spectrum disorder (ASD) has not yet been fully clarified, converging lines of evidence implicated a role of neuroinflammation in the etiological pathway of this disorder. The present article provided a systematic review of publications regarding the involvement of different components of neuroinflammation in postmortem brain samples of subjects diagnosed with ASD. A systematic search of PubMed, Embase, and Web of Science was conducted, which was supplemented by manual searching of reference lists of included articles. The screening for study and extraction of data were conducted by two independent authors after reviewing the abstract and full text. Of 356 articles identified in the literature search, 27 articles comprising 685 subjects (ASD = 313, controls = 351, schizophrenia = 10, epilepsy = 11) covering 19 brain regions met the eligibility criteria for this review. The search yielded 11 studies that estimated astrocyte-related changes, 8 studies that reported microglia-related changes, 2 studies that evaluated oligodendrocyte-related changes, 3 studies that examined changes in glial cells without differentiating cell types, 6 studies that evaluated the levels of cytokines and chemokines, and 7 studies that measured other inflammatory parameters in postmortem brain samples of subjects with ASD compared with controls. Although a few studies noted a lack of changes in neuroinflammatory markers in postmortem brain samples of ASD subjects, the majority of studies supported the presence of neuroinflammation in the neurobiological pattern of ASD as shown by activation of astrocytes and microglia together with abnormal levels of cytokines and chemokines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.