SynthesisCardiovascular diabetology2020
Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.
Synthesis in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06067451 (Impact of SMART GOAL Setting Protocol on Body Weight and Metabolic Parameters in Children and Adolescents With Prediabetes; a Randomized Clinical Trial.), which is not on this map. Cited by 177 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of SMART GOAL Setting Protocol on Body Weight and Metabolic Parameters in Children and Adolescents With Prediabetes; a Randomized Clinical Trial.
Who cites it
177 citing papers in PubMed, 13 syntheses or guidelines pooled it, 305 citations in OpenAlex.
- Adolescent obesity and risk of serious chronic morbidity and mortality in young adulthood: a systematic review of cohorts from national registries.Cardiovascular diabetology · 2026Pooled it
- Does physical activity really improve anxiety and depression in overweight or obese children and adolescents? A systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- Evaluating the prognostic value of body mass index in diffuse large B-cell lymphoma: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Impact of exercise on anthropometric outcomes in children and adolescents with overweight or obesity: a systematic review and meta-analysis based on 113 randomized controlled trials worldwide.BMC public health · 2025Pooled it
- New Perspectives in Modulating the Entero-Insular Axis in Pediatric Obesity.International journal of molecular sciences · 2025Pooled it
- Association between early age body mass index and the risk of adulthood cardiovascular diseases: a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Mechanisms underlying obesity-malignancy connection: a systematic narrative review.Journal of physiology and biochemistry · 2025Pooled it
- The divergent association of diet intake, parental education, and nutrition policy with childhood overweight and obesity from low- to high-income countries: A meta-analysis.Journal of global health · 2024Pooled it
- Quantifying the increased risk of illness in malnourished children: a global meta-analysis and propensity score matching approach.Global health research and policy · 2024Pooled it
- Body composition in patients with Fontan physiology: a systematic review.European journal of pediatrics · 2023Pooled it
- Surgery for the treatment of obesity in children and adolescents.The Cochrane database of systematic reviews · 2022Pooled it
- Effectiveness of multiple eHealth-delivered lifestyle strategies for preventing or intervening overweight/obesity among children and adolescents: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Effect of High-Intensity Functional Training with Basketball on Cardiorespiratory Fitness and Functional Movement Performance in Obese Adolescents.Medicine and science in sports and exercise · 2026Trial
- Effects of an Exercise Intervention Based on mHealth Technology on the Physical Health of Male University Students With Overweight and Obesity: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Effects of high-intensity interval training combined with dietary intervention on body composition, cardiovascular function, endothelial cell function and blood lipid indexes in children with obesity: a randomized controlled trial.Frontiers in public health · 2025Trial
- Trial
- A pediatric primary care practice-based obesity intervention to support families: a cluster-randomized clinical trial.Obesity (Silver Spring, Md.) · 2024Trial
- Article
- Article
117 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe obesity among children and adolescents is a significant global public health concern. The prevalence has markedly increased over the last decades, becoming common in many countries. Overwhelming rates of obesity among youth have prompted efforts to identify an evidence-based immediate- and long-term cardiometabolic risk factor profile in childhood-onset severe obesity, and to highlight gaps that require further investigation. The PubMed database was systematically searched in accordance with PRISMA guidelines. The search yielded 831 results, of which 60 fulfilled stringent criteria and were summarized in this review. The definition of severe obesity was variable, with only one half the publications using the definition BMI > 120% of the 95th percentile. Point estimates of the prevalence of at least one cardiometabolic risk factor in children with severe obesity reportedly range from 67 to 86%. Cross-sectional studies indicate that children and adolescents with severe obesity are at greater risk than those with mild obesity for type 2 diabetes, hypertension, fatty liver disease and dyslipidemia, already at childhood and adolescence. Robust epidemiological data on the long-term risk and actual point estimates in adulthood are lacking for these diseases as well as for other diseases (coronary heart disease, stroke, chronic kidney disease and cancer). Recent longitudinal studies indicate an increased risk for cardiomyopathy, heart failure, cardiovascular mortality and all-cause mortality in adulthood for adolescents with severe obesity compared to those with mild obesity. Given the alarming increase in the prevalence of severe obesity, the persistence of adiposity from childhood to adulthood and the precarious course of young adults with chronic comorbidities, the economic and clinical services burden on the healthcare system is expected to rise.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.