Evidence map›Paper›PMID 32541011›Full record

ArticleDevelopment (Cambridge, England)2020

Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure.

Katie L Sinagoga, Alessandra M Larimer-Picciani, Stephanie M George, Samantha A Spencer, James A Lister, Jeffrey M Gross

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Katie L SinagogaDepartments of Ophthalmology and Developmental Biology, Louis J. Fox Center for Vision Restoration, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Alessandra M Larimer-PiccianiDepartments of Ophthalmology and Developmental Biology, Louis J. Fox Center for Vision Restoration, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Stephanie M GeorgeDepartments of Ophthalmology and Developmental Biology, Louis J. Fox Center for Vision Restoration, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Samantha A SpencerDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
James A ListerDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Jeffrey M GrossDepartments of Ophthalmology and Developmental Biology, Louis J. Fox Center for Vision Restoration, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA grossjm@pitt.edu.ORCID 0000-0002-9422-6312
University of Pittsburgh · USVirginia Commonwealth University · US

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 1989 to 2026
$17.8M
Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Interdisciplinary Visual Sciences (IVS) Traininig ProgramT32EY017271 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Marlene Behrmann, Paul R. Kinchington · 2008 to 2026
$3.6M
Genetic Regulation of Eye Development in ZebrafishR01EY018005 · NEI · UNIVERSITY OF TEXAS AT AUSTIN · PI GROSS, JEFFREY · 2008 to 2017
$3.3M
NCATS NIH HHS UL1 TR000058NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY018005NEI NIH HHS T32 EY017271
6 · The paper itself

Abstract

A crucial step in eye development is the closure of the choroid fissure (CF), a transient structure in the ventral optic cup through which vasculature enters the eye and ganglion cell axons exit. Although many factors have been identified that function during CF closure, the molecular and cellular mechanisms mediating this process remain poorly understood. Failure of CF closure results in colobomas. Recently,

Indexed as

AnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsChoroidColobomaEmbryo, MammalianHumansMicrophthalmia-Associated Transcription FactorMutationNeural CrestRetinal Pigment EpitheliumSkullZebrafishZebrafish ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMicrophthalmia-Associated Transcription Factormitfa protein, zebrafishTfec protein, zebrafishZebrafish ProteinsChoroid fissureColobomaMitfNeural crestZebrafish

Identifiers

PMID32541011
PMCPMC7375471
OpenAlexW3034811939

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.