Evidence map›Paper›PMID 32544802›Full record

SynthesisCritical reviews in oncology/hematology2020

COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature.

Giuseppe Di Lorenzo, Rossella Di Trolio, Zisis Kozlakidis, Giuseppina Busto, Concetta Ingenito, Luciana Buonerba, Claudia Ferrara, Annamaria Libroia, Gianluca Ragone, Concetta Dello Ioio and 5 more

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Critical reviews in oncology/hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 67 citations in OpenAlex.

  1. Role of Cytochrome P450 2C9 in COVID-19 Treatment: Current Status and Future Directions.European journal of drug metabolism and pharmacokinetics · 2023
    Review
  2. Review
  3. Potential interactions between antineoplastic agents and medicines used to treat Covid-19.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2022
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Screening of potential inhibitors of COVID-19 with repurposing approach via molecular docking.Network modeling and analysis in health informatics and bioinformatics · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. The Deadly Duo of COVID-19 and Cancer!Frontiers in molecular biosciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Giuseppe Di LorenzoOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy; Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy. Electronic address: direttoreuocpagani@gmail.com.
Rossella Di TrolioUnit of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Via Mariano Semmola, Naples, Italy.
Zisis KozlakidisInternational Agency for Research on Cancer, World Health Organization, 150 cours Albert Thomas, 69372 Lyon, France.
Giuseppina BustoOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Concetta IngenitoOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Luciana BuonerbaOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Claudia FerraraOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Annamaria LibroiaOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Gianluca RagoneOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Concetta Dello IoioOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Beatrice SavastanoOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Mario PolverinoOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Ferdinando De FalcoOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Simona IaccarinoOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Emilio LeoOncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
CTO Andrea Alesini · ITCentre international de recherche sur le cancer · FRIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Molise · IT

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundIt is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID- 19).

methodsWe conducted a literature review on https://www.ncbi.nlm.nih.gov/pubmed/, https://scholar.google.com, www.arxiv.org, www.biorxiv.org, of all articles published using the keywords COVID-19 therapy or treatment and cancer until May 2, 2020. A total of 205 articles were identified and 53 were included in this review.

resultsWe describe the ongoing COVID-19 therapies that should be known by oncologists and highlight the potential interactions with antineoplastic drugs, commonly used in clinical practice. The main drug interactions were found with tocilizumab, ruxolitinib and colchicine.

conclusionsThe literature provides an inconclusive picture on potential preferred treatments for COVID-19 and their interactions with antineoplastic agents. Future clinical trials are needed to better understand the interactions between different drugs in the context of COVID-19 pandemic.

Indexed as

Coronavirus InfectionsPandemicsPneumonia, ViralAntineoplastic AgentsBetacoronavirusCOVID-19COVID-19 Drug TreatmentHumansSARS-CoV-2Antineoplastic AgentsAntiviral therapyCancerCoronavirus disease SARS-CoV-2 (COVID-19)Drug-interactionsManagement

Identifiers

PMID32544802
PMCPMC7239789
OpenAlexW3028287286

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.