Evidence map›Paper›PMID 32545192›Full record

ReviewInternational journal of molecular sciences2020

Prion Protein in Stem Cells: A Lipid Raft Component Involved in the Cellular Differentiation Process.

Stefano Martellucci, Costantino Santacroce, Francesca Santilli, Valeria Manganelli, Maurizio Sorice, Vincenzo Mattei

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. DMP1-mediated transformation of DPSCs to CD31Frontiers in cell and developmental biology · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. PrPFrontiers in molecular neuroscience · 2021
    Review
  18. Prion Protein at the Leading Edge: Its Role in Cell Motility.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Stefano MartellucciDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-3952-3162
Costantino SantacroceBiomedicine and Advanced Technologies Rieti Center, "Sabina Universitas", 02100, Rieti, Italy.
Francesca SantilliBiomedicine and Advanced Technologies Rieti Center, "Sabina Universitas", 02100, Rieti, Italy.ORCID 0000-0003-0863-2996
Valeria ManganelliDepartment of Experimental Medicine, "Sapienza" University, 00161 Rome, Italy.
Maurizio SoriceDepartment of Experimental Medicine, "Sapienza" University, 00161 Rome, Italy.
Vincenzo MatteiBiomedicine and Advanced Technologies Rieti Center, "Sabina Universitas", 02100, Rieti, Italy.ORCID 0000-0003-4677-088X
Sapienza University of Rome · ITUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prion protein (PrP) is an enigmatic molecule with a pleiotropic effect on different cell types; it is localized stably in lipid raft microdomains and it is able to recruit downstream signal transduction pathways by its interaction with various biochemical partners. Since its discovery, this lipid raft component has been involved in several functions, although most of the publications focused on the pathological role of the protein. Recent studies report a key role of cellular prion protein (PrP

Indexed as

AnimalsCell DifferentiationHumansMembrane MicrodomainsNeuronsPrPC ProteinsStem CellsPrPC Proteinslipid raftmesenchymal stem cellsprion proteinprionsraft microdomainsraftsstem cells

Identifiers

PMID32545192
PMCPMC7312503
OpenAlexW3034288561

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.