Evidence map›Paper›PMID 32546549›Full record

ReviewBMJ open diabetes research & care2020

Hypoglycemia in patient with type 2 diabetes treated with insulin: it can happen.

Simon R Heller, Mark Peyrot, Shannon K Oates, April D Taylor

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  13. Evaluating the toxicity and efficacy of the endophytic bacteriumBiochemistry and biophysics reports · 2025
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  20. [Main clinical factors associated with hypoglycemia in patients with type 2 diabetes].Revista medica del Instituto Mexicano del Seguro Social · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Simon R HellerEndocrinology & Metabolism, University of Sheffield, Sheffield, UK.
Mark PeyrotSociology, Loyola University Maryland, Baltimore, Maryland, USA.
Shannon K OatesEndocrinology & Metabolism, Indiana University Health Arnett Hospital, Lafayette, Indiana, USA.
April D TaylorMedical Development, Lilly USA, Indianapolis, Indiana, USA taylor_april_dawn@lilly.com.ORCID 0000-0002-6725-1942
Eli Lilly (United States) · USIndiana University Health · USLoyola University Maryland · USUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are many misconceptions about the prevalence and effects of hypoglycemia in people with type 2 diabetes (T2D), including hypoglycemia does not occur or does not have adverse consequences in T2D. This narrative review aims to help dispel these myths. Around 25% of people with T2D taking insulin for >5 years were found to have severe hypoglycemic events, which is comparable to the severe hypoglycemia rate in adults with type 1 diabetes (T1D) diagnosed within 5 years. The total number of hypoglycemic events among insulin-treated T2D, including severe hypoglycemia, is as high or higher than among those with T1D. Recent evidence suggests serious consequences of hypoglycemia may, in some respects, be greater in individuals with T2D, particularly regarding effects on the cardiovascular system. Hypoglycemia is generally patient-reported. Issues with hypoglycemia unawareness, limited glucose testing, limited recall, lack of event logging and fear of failure or shaming limits the number of hypoglycemic episodes reported by people with diabetes. Barriers to healthcare provider inquiry and reporting include lack of knowledge regarding the problem's magnitude, competing priorities during patient visits, lack of incentives to report and limitations to documentation systems for adequate reporting. All people with diabetes should be encouraged to discuss their experiences with hypoglycemia without judgment or shame. Glucose targets, testing schedules (blood glucose or continuous glucose monitoring) and treatment plans should be reviewed often and individualized to the minimize risk of hypoglycemia. Finally, people with T2D on insulin should always be encouraged to have oral glucose and rescue medication immediately available.

Indexed as

Diabetes Mellitus, Type 2HypoglycemiaAdultBlood GlucoseBlood Glucose Self-MonitoringHumansInsulinBlood GlucoseInsulinhypoglycemiainsulinpreventiontype 2 diabetes

Identifiers

PMID32546549
PMCPMC7299018
OpenAlexW3034287678

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.