ArticleInternational journal of nanomedicine2020
TiO
Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Titanium dioxide dental implants surfaces related oxidative stress in bone remodeling: a systematic review.PeerJ · 2022Pooled it
- Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes.Advanced healthcare materials · 2026Review
- Mechanochemically reprogrammed porous tantalum with synergistic antibacterial and osteogenic properties for the treatment of infectious bone defects.Journal of nanobiotechnology · 2025Article
- Microenvironment-responsive nanoparticles functionalized titanium implants mediate redox balance and immunomodulation for enhanced osseointegration.Materials today. Bio · 2025Article
- Differential expression of osteoblast-like cells on self-organized titanium dioxide nanotubes.Journal of dental sciences · 2024Article
- Potential role of metal nanoparticles in treatment of peri-implant mucositis and peri-implantitis.Biomedical engineering online · 2024Review
- Biomaterials Designed to Modulate Reactive Oxygen Species for Enhanced Bone Regeneration in Diabetic Conditions.Journal of functional biomaterials · 2024Review
- Nano-Based Approaches in Surface Modifications of Dental Implants: A Literature Review.Molecules (Basel, Switzerland) · 2024Review
- Strategies for Improving Impaired Osseointegration in Compromised Animal Models.Journal of dental research · 2024Review
- Elucidating the Mechanism of Large-Diameter Titanium Dioxide Nanotubes in Protecting Osteoblasts Under Oxidative Stress Environment: The Role of Fibronectin and Albumin Adsorption.International journal of nanomedicine · 2024Article
- Applications of Titanium Dioxide Nanostructure in Stomatology.Molecules (Basel, Switzerland) · 2022Review
- A two-phase and long-lasting multi-antibacterial coating enables titanium biomaterials to prevent implants-related infections.Materials today. Bio · 2022Article
- Recovering Osteoblast Functionality on TiOInternational journal of nanomedicine · 2022Article
- Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients.Nanomaterials (Basel, Switzerland) · 2021Review
- Bioadaptation of implants to In vitro and In vivo oxidative stress pathological conditions via nanotopography-induced FoxO1 signaling pathways to enhance Osteoimmunal regeneration.Bioactive materials · 2021Article
- 3D Printed Ti-6Al-4V Implant with a Micro/Nanostructured Surface and Its Cellular Responses.ACS omega · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with diabetes mellitus (DM) have a higher failure rate of dental implant treatments. However, whether titanium (Ti) implants with TiO MATERIALS AND
methodsPure Ti discs were surface treated into the polishing (mechanically polished, MP), sandblasted and acid-etched (SLA), and TNT groups. Scanning electron microscopy was used to examine the surface morphology. The cell adhesion and proliferation ability on different modified Ti surfaces at various glucose concentrations (5.5, 11, 16.5, and 22 mM) was detected by the CCK-8 assay. The osteogenetic ability on different modified Ti surfaces under high-glucose conditions was evaluated by alkaline phosphatase (ALP), osteopontin (OPN) immunofluorescence, Western blot, and Alizarin Red staining in vitro. Detection of cell apoptosis and intracellular reactive oxygen species (ROS) was undertaken both before and after N-acetylcysteine (NAC) treatment to assess the oxidative stress associated with different modified Ti surfaces under high-glucose conditions. An in vivo study was conducted in DM rats with different modified Ti femoral implants. The osteogenetic ability of different modified Ti implants in DM rats was assessed using a micro-CT scan.
resultsHigh-glucose conditions inhibited cell adhesion, proliferation, and osteogenetic ability of different modified Ti surfaces. High-glucose conditions induced higher apoptosis rate and intracellular ROS level on different modified Ti surfaces; these effects were alleviated by NAC. Compared with the SLA surface, the TNT surface alleviated the osteogenetic inhibition induced by high-glucose states by reversing the overproduction of ROS in vitro. In the in vivo experiment, micro-CT scan analysis further confirmed the best osteogenetic ability of TNT surface in rats with DM.
conclusionTNT surface modification alleviates osteogenetic inhibition induced by DM. It may provide a more favorable Ti implant surface for patients with DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.