Evidence map›Paper›PMID 32555422›Full record

ArticleMolecular psychiatry2021

Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior.

Xiao Yu, Wei Ba, Guangchao Zhao, Ying Ma, Edward C Harding, Lu Yin, Dan Wang, Huiming Li, Peng Zhang, Youran Shi and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Xiao Yu *Department of Life Sciences, Imperial College London, London, UK. x.yu10@imperial.ac.uk.ORCID http://orcid.org/0000-0001-9441-1705
Wei Ba *Department of Life Sciences, Imperial College London, London, UK.
Guangchao Zhao *Department of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
Ying MaDepartment of Life Sciences, Imperial College London, London, UK.
Edward C HardingDepartment of Life Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5803-2780
Lu YinDepartment of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
Dan WangDepartment of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
Huiming LiDepartment of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
Peng ZhangDepartment of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
Youran ShiDepartment of Life Sciences, Imperial College London, London, UK.
Raquel YustosDepartment of Life Sciences, Imperial College London, London, UK.
Alexei L VyssotskiInstitute of Neuroinformatics, University of Zürich/ETH Zürich, Zurich, Switzerland.
Hailong DongDepartment of Anesthesiology & Perioperative Medicine, Xijing Hospital, Xi'an, Shanxi, China.
Nicholas P FranksDepartment of Life Sciences, Imperial College London, London, UK. n.franks@imperial.ac.uk.ORCID http://orcid.org/0000-0003-4874-4212
William WisdenDepartment of Life Sciences, Imperial College London, London, UK. w.wisden@imperial.ac.uk.ORCID http://orcid.org/0000-0003-4743-0334
Imperial College London · GBXijing Hospital · CNUK Dementia Research Institute · GBSIB Swiss Institute of Bioinformatics · CH

Funding

Wellcome Trust 107839Wellcome Trust 107841Wellcome Trust (Wellcome) 107841/Z/15/Z
6 · The paper itself

Abstract

The ventral tegmental area (VTA), an important source of dopamine, regulates goal- and reward-directed and social behaviors, wakefulness, and sleep. Hyperactivation of dopamine neurons generates behavioral pathologies. But any roles of non-dopamine VTA neurons in psychiatric illness have been little explored. Lesioning or chemogenetically inhibiting VTA GABAergic (VTA

Indexed as

GABAergic NeuronsVentral Tegmental AreaAnimalsDopaminergic NeuronsHypothalamic Area, LateralManiaMice

Identifiers

PMID32555422
PMCPMC8589652
OpenAlexW3036899738

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.