ArticleScientific reports2020
Sex differences in the genetic architecture of depression.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure.Briefings in bioinformatics · 2022Pooled it
- The association of objectively and subjectively measured modifiable lifestyle factors with internalizing problems: the role of genetic confounding and shared method variance bias.Social psychiatry and psychiatric epidemiology · 2026Article
- Peripartum Depression as a Heart-Brain-Endocrine-Immune Syndrome: Neuroendocrine, Cardiovascular, and Inflammatory Pathways Underlying Maternal Vulnerability.Life (Basel, Switzerland) · 2026Review
- Association of Psychiatric Disorder Comorbidities With Global and Orbital Ablative Surgeries: A Real-World Retrospective Cohort Study.Psychiatry investigation · 2026Article
- Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Global Burden of Depressive Disorders, 1990-2021, During the COVID-19 Pandemic and Projections to 2050: A Global Burden of Disease Study 2021.Psychiatry investigation · 2025Article
- Analysis of Genomic and Transcriptomic Data Revealed Key Genes and Processes in the Development of Major Depressive Disorder.International journal of molecular sciences · 2025Article
- Mechanisms Underlying Treatment-Resistant Depression: Exploring Sex-Based Biological Differences.Journal of neurochemistry · 2025Review
- Sex differences in the network structures of depressive symptom profiles in Asian patients with depressive disorders: findings from the Research on Asian Psychotropic Patterns for Antidepressants, Phase 3.Acta neuropsychiatrica · 2025Article
- Gender as a sensor of nurses' depression, compassion fatigue and resilience.BMC psychiatry · 2025Article
- Sex-Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome-Wide Association Study of All of Us and UK Biobank Data.Genetic epidemiology · 2025Article
- Moderating Effect of Muscular Strength in the Association Between Cancer and Depressive Symptomatology.Healthcare (Basel, Switzerland) · 2025Article
- Potential Impact of Choline Alphoscerate on Depressive Symptoms in Association with Insulin Resistance in Elderly Patients with Type 2 Diabetes.Journal of clinical medicine · 2025Article
- The Etiopathogenic Mosaic of Suicidal Behaviour.Behavioral sciences (Basel, Switzerland) · 2025Review
- An evolutionary concept analysis of depression in Black mothers.Archives of psychiatric nursing · 2024Review
- The affective factors of depression symptoms in hypertensive patients and the protective effect of physical activity.Sleep & breathing = Schlaf & Atmung · 2024Article
- Sex-Differential Gene Expression in Developing Human Cortex and Its Intersection With Autism Risk Pathways.Biological psychiatry global open science · 2024Article
- Review
- Sex differences in plasma proteomic markers in late-life depression.Psychiatry research · 2024Article
- Masculine depression and its problem behaviors: use alcohol and drugs, work hard, and avoid psychiatry!European archives of psychiatry and clinical neuroscience · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence and clinical characteristics of depressive disorders differ between women and men; however, the genetic contribution to sex differences in depressive disorders has not been elucidated. To evaluate sex-specific differences in the genetic architecture of depression, whole exome sequencing of samples from 1000 patients (70.7% female) with depressive disorder was conducted. Control data from healthy individuals with no psychiatric disorder (n = 72, 26.4% female) and East-Asian subpopulation 1000 Genome Project data (n = 207, 50.7% female) were included. The genetic variation between men and women was directly compared using both qualitative and quantitative research designs. Qualitative analysis identified five genetic markers potentially associated with increased risk of depressive disorder in females, including three variants (rs201432982 within PDE4A, and rs62640397 and rs79442975 within FDX1L) mapping to chromosome 19p13.2 and two novel variants (rs820182 and rs820148) within MYO15B at the chromosome 17p25.1 locus. Depressed patients homozygous for these variants showed more severe depressive symptoms and higher suicidality than those who were not homozygotes (i.e., heterozygotes and homozygotes for the non-associated allele). Quantitative analysis demonstrated that the genetic burden of protein-truncating and deleterious variants was higher in males than females, even after permutation testing. Our study provides novel genetic evidence that the higher prevalence of depressive disorders in women may be attributable to inherited variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.