Evidence map›Paper›PMID 32556595›Full record

Trial reportMetabolomics : Official journal of the Metabolomic Society2020

Preliminary evidence of effects of potassium chloride on a metabolomic path to diabetes and cardiovascular disease.

Ranee Chatterjee, Clemontina A Davenport, Lydia Kwee, David D'Alessio, Laura P Svetkey, Pao-Hwa Lin, Cris A Slentz, Olga Ilkayeva, Johanna Johnson, David Edelman and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Metabolomics : Official journal of the Metabolomic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02236598 (The Effects of Potassium on Glucose Metabolism in African Americans), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02236598 phase2completednot on this map

The Effects of Potassium on Glucose Metabolism in African Americans

TypeinterventionalSponsorDuke UniversityRan2015 to 2016Enrolled61ConditionsBorderline HypokalemiaArmsK+ supplement, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ranee ChatterjeeDepartment of Medicine, Duke University, 200 Morris Street, 3rd Floor, Durham, NC, 27701, USA. ranee.chatterjee@duke.edu.ORCID 0000-0002-4294-8081
Clemontina A DavenportDepartment of Medicine, Duke University, 200 Morris Street, 3rd Floor, Durham, NC, 27701, USA.
Lydia KweeDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
David D'AlessioDepartment of Medicine, Duke University, 200 Morris Street, 3rd Floor, Durham, NC, 27701, USA.
Laura P SvetkeyDepartment of Medicine, Duke University, 200 Morris Street, 3rd Floor, Durham, NC, 27701, USA.
Pao-Hwa LinDepartment of Medicine, Duke University, 200 Morris Street, 3rd Floor, Durham, NC, 27701, USA.
Cris A SlentzDepartment of Medicine, Duke University, 200 Morris Street, 3rd Floor, Durham, NC, 27701, USA.
Olga IlkayevaDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
Johanna JohnsonDuke Molecular Physiology Institute, Duke University, Durham, NC, USA.
David EdelmanDepartment of Medicine, Duke University, 200 Morris Street, 3rd Floor, Durham, NC, 27701, USA.
Svati H ShahDepartment of Medicine, Duke University, 200 Morris Street, 3rd Floor, Durham, NC, 27701, USA.
Duke University · US

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
Renal Genomics CoreP30DK096493 · NIDDK · DUKE UNIVERSITY · PI FOSTER, MARY H., SVETKEY, LAURA P · 2012 to 2016
$5.9M
Duke CTSA (Composite)KL2TR001115 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, KRAFT, MONICA · 2013 to 2017
$5.1M
A Personalized Metabolomic Approach to Human Obesity and Weight LossR01HL127009 · NHLBI · DUKE UNIVERSITY · PI SHAH, SVATI H. · 2016 to 2019
$2.1M
NCATS NIH HHS KL2 TR001115NCATS NIH HHS UL1 TR002553NHLBI NIH HHS R01 HL127009NIDDK NIH HHS P30 DK096493
6 · The paper itself

Abstract

introductionLow potassium intake can affect cardiovascular disease (CVD) risk and cardiometabolic risk factors.

objectiveWe hypothesize that potassium chloride (KCl) supplementation can improve cardiovascular risk metabolomic profile.

methodsIn this secondary analysis of a pilot randomized clinical trial (RCT) of 26 participants with prediabetes randomized to KCl or placebo, we performed targeted mass-spectrometry-based metabolomic profiling on baseline and 12-week (end-of-study) plasma samples. Principal component analysis (PCA) was used to reduce the many correlated metabolites into fewer, independent factors that retain most of the information in the original data.

resultsThose taking KCl had significant reductions (corresponding to lower cardiovascular risk) in the branched-chain amino acids (BCAA) factor (P = 0.004) and in valine levels (P = 0.02); and non-significant reductions in short-chain acylcarnitines (SCA) factor (P = 0.11).

conclusionsKCl supplementation may improve circulating BCAA levels, which may reflect improvements in overall cardiometabolic risk profile. CLINICAL TRIALS REGISTRY: Clinicaltrials.gov identifier: NCT02236598; https://clinicaltrials.gov/ct2/show/NCT02236598.

Indexed as

Blood GlucoseCardiovascular DiseasesDiabetes MellitusFemaleGlucoseHumansMaleMass SpectrometryMetabolomeMetabolomicsMiddle AgedPilot ProjectsPlasmaPotassium ChlorideRisk FactorsBlood GlucoseGlucosePotassium ChlorideBranched-chain amino acidsCardiovascular disease riskMetabolitesPotassium chloridePotassium supplementsPrediabetes

Identifiers

PMID32556595
PMCPMC8053254
OpenAlexW3036473049

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.