SynthesisBrain and behavior2020
Altered functional connectivity of brain regions based on a meta-analysis in patients with T2DM: A resting-state fMRI study.
Synthesis in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging.Frontiers in neurology · 2022Pooled it
- Altered functional connectivity of brain regions based on a meta-analysis in patients with T2DM: A resting-state fMRI study.Brain and behavior · 2020Pooled it
- Investigating the impact of type 2 diabetes mellitus on brain function in obstructive sleep apnea patients using regional homogeneity and seed-based functional connectivity methods.Frontiers in neuroscience · 2025Article
- The Interaction of Glycemia with Anxiety and Depression Is Related to Altered Cerebellar and Cerebral Functional Correlations.Brain sciences · 2023Article
- Altered dynamic effective connectivity of the default mode network in type 2 diabetes.Frontiers in neurology · 2023Article
- Association between gene expression and altered resting-state functional networks in type 2 diabetes.Frontiers in aging neuroscience · 2023Article
- Abnormal functional connectivity in the right dorsal anterior insula associated with cognitive dysfunction in patients with type 2 diabetes mellitus.Brain and behavior · 2022Article
- Altered Regional Homogeneity in Patients With Diabetic Erectile Dysfunction: A Resting-State fMRI Study.Frontiers in endocrinology · 2022Article
- Turning data into better mental health: Past, present, and future.Frontiers in digital health · 2022Review
- Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults.Frontiers in integrative neuroscience · 2022Article
- Concomitant functional impairment and reorganization in the linkage between the cerebellum and default mode network in patients with type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2021Article
- Altered Gray Matter Volume, Functional Connectivity, and Degree Centrality in Early-Onset Type 2 Diabetes Mellitus.Frontiers in neurology · 2021Article
- Aberrant Brain Functional Connectivity Strength and Effective Connectivity in Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo explore the neural mechanisms of brain impairment in type 2 diabetes mellitus (T2DM), abnormal changes to the functional connections between brain regions in the resting state were investigated based on a meta-analysis.
methodsResting-state functional magnetic resonance imaging (fMRI) and neuropsychological assessment were performed on 38 patients with T2DM and 33 healthy controls (HCs). Functional connectivity between regions based on a meta-analysis and other voxels in the brain was calculated and compared between the two groups using a two-sample t test. A correlation analysis was conducted between clinical/cognitive variables and functional connection values from the regions with significant differences in the above comparison.
resultsPatients in the T2DM group showed a significantly decreased functional connection between the right posterior cerebellum and the right middle/inferior occipital gyrus, left middle temporal gyrus, left superior frontal gyrus, left middle frontal gyrus, left insula, left precuneus, and right paracentral lobule/left precuneus when compared with HC group. The functional connection values between the right insula and left medial frontal gyrus, left supplementary motor area, and between the left lingual gyrus and right middle/inferior occipital gyrus in patients with T2DM were significantly decreased. Moreover, the functional connection values between the right posterior cerebellum and left middle frontal gyrus, and between the right posterior cerebellum and left precuneus were negatively correlated with HbA1c in the T2DM group (r = -.356, p = .03; r = -.334, p = .043).
conclusionsOur study showed a wide range of cerebellar-cerebral circuit abnormalities in patients with T2DM, which provides a new direction to investigate the neuropathological mechanisms of T2DM from the perspective of the cerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.