ReviewInternational journal of molecular sciences2020
Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
169 citing papers in PubMed, 3 syntheses or guidelines pooled it, 414 citations in OpenAlex.
- A systematic review of air pollution exposure and brain structure and function during development.Environmental research · 2025Pooled it
- Particulate air pollution and cardiovascular disease mortality in Jiangsu Province, China: a time-series analysis between 2015 and 2021.Frontiers in public health · 2023Pooled it
- Air pollution, depressive and anxiety disorders, and brain effects: A systematic review.Neurotoxicology · 2022Pooled it
- Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings.Journal of environmental health science & engineering · 2026Review
- The Association Between Living Environment and Depression: The Mediating Role of Sleep Duration.Journal of prevention (2022) · 2026Article
- Air quality and health implications of exposure to ultrafine particle pollution.Cardiovascular research · 2026Article
- Beyond air pollution: Green space, water minerals, and genetic predisposition in migraine onset.iScience · 2026Article
- Preconception and early-pregnancy exposure to ambient air pollution and trajectories of depressive symptoms during pregnancy.Environmental health : a global access science source · 2026Article
- FDA Approval of Donanemab-azbt: A New Dawn in Alzheimer's Disease Treatment.Health science reports · 2026Article
- Safety and Efficacy of Inhaled Natural Product Powders That Enhance Mucociliary Clearance.AAPS PharmSciTech · 2026Article
- Cellular responses of human Muller glia exposed to test dust pollution.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Incense Aerosol-Induced Neurotoxicity Disrupts α-Synuclein Homeostasis in a Cellular Parkinson's Disease Model, Distinct from Cigarette Aerosols.Chemical research in toxicology · 2026Article
- Ambient air pollution exposure accelerates the occurrence of 78 non-communicable chronic diseases: an accelerated failure time analysis of a nationwide cohort.GeroScience · 2026Article
- Association of air pollution and depressive symptoms with cardiometabolic Multimorbidity in middle-aged and older adults: an analysis based on the China health and retirement longitudinal study (CHARLS).Acta diabetologica · 2026Article
- Impact of multiple air pollutants on probable sarcopenia in the UK population: the mediating role of physical activity and biological aging.BMC public health · 2026Article
- Sex differences in the relationship between household solid fuel use and incident stroke and the mediating role of depressive symptoms in middle-aged and older Chinese adults.BMC public health · 2026Article
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- The role of comorbidities in the associations between air pollution and Alzheimer's disease: A national cohort study in the American Medicare population.PLoS medicine · 2026Article
- Beyond the Brain: Exploring the multi-organ axes in Parkinson's disease pathogenesis.Journal of advanced research · 2026Review
109 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Exposure to ambient air pollution is a well-established determinant of health and disease. The Lancet Commission on pollution and health concludes that air pollution is the leading environmental cause of global disease and premature death. Indeed, there is a growing body of evidence that links air pollution not only to adverse cardiorespiratory effects but also to increased risk of cerebrovascular and neuropsychiatric disorders. Despite being a relatively new area of investigation, overall, there is mounting recent evidence showing that exposure to multiple air pollutants, in particular to fine particles, may affect the central nervous system (CNS) and brain health, thereby contributing to increased risk of stroke, dementia, Parkinson's disease, cognitive dysfunction, neurodevelopmental disorders, depression and other related conditions. The underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests inflammation and oxidative stress to be crucial factors in the pathogenesis of air pollution-induced disorders, driven by the enhanced production of proinflammatory mediators and reactive oxygen species in response to exposure to various air pollutants. From a public health perspective, mitigation measures are urgent to reduce the burden of disease and premature mortality from ambient air pollution.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.