ReviewExperimental eye research2020
Biological functions of tear film.
Review in Experimental eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 180 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation Of Dry Eye After Uneventful Phacoemulsification
Combination Therapy of Vevye and Flarex for Dry Eye Disease
Who cites it
180 citing papers in PubMed, 4 syntheses or guidelines pooled it, 284 citations in OpenAlex.
- Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in Ocular Surface Disorders.Translational vision science & technology · 2026Pooled it
- Lymphocyte Subpopulations in the Healthy Human Lacrimal Gland and Their Variations With Age and Sex, Systematic Review 1960-2023.Immunity, inflammation and disease · 2025Pooled it
- Dry eye post-cataract surgery: a systematic review and meta-analysis.BMC ophthalmology · 2025Pooled it
- Topical Omega-3 Fatty Acids Eyedrops in the Treatment of Dry Eye and Ocular Surface Disease: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Comparison of immediate therapeutic effects of 3% diquafosol and 2% rebamipide in dry eye disease: a prospective, randomized, paired-eye trial.Scientific reports · 2026Trial
- Effects of a propylene glycol-hydroxypropyl guar nanoemulsion in patients with mild to moderate dry eye disease.International ophthalmology · 2025Trial
- A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry eye disease.Stem cell research & therapy · 2025Trial
- Immediate Effects of Light Mode and Dark Mode Features on Visual Fatigue in Tablet Users.International journal of environmental research and public health · 2025Trial
- Infraorbital Skin Application of Menthol Emulsion for Dry Eye Disease: A Randomized Clinical Trial.Ophthalmology and therapy · 2026Article
- Long-Term Ocular Outcomes of Dupilumab in Atopic Dermatitis: Results From the BioDay Registry.Clinical and translational allergy · 2026Article
- Article
- Characteristics of Tear Film in Sjögren's Syndrome Patients as Measured by a Novel Tear Film Imager: A Pilot Study.Journal of clinical medicine · 2026Article
- Nanosuspension-based Ocular Therapeutics for Infection Control: Integrating Mucin Interactions and Tear Film Dynamics.AAPS PharmSciTech · 2026Review
- Canine Tear Proteomics: A New Frontier in Veterinary Ophthalmology.Veterinary ophthalmology · 2026Review
- Liposomal Drug Delivery in Ocular Therapy: Strategies for Enhancing Corneal Penetration and Bioavailability.Cells · 2026Review
- Meibomian Gland-Mediated Drug Delivery via Eyelid Application of Troxipide Nanoparticles Improves an N-Acetylcysteine-Induced Dry Eye.Pharmaceutics · 2026Article
- Regional Tear Film Quality Changes Across Eye Gaze Directions Revealed by Spatial Mapping and Threshold Sensitivity Analysis.Journal of clinical medicine · 2026Article
- Tear Film Changes Following Anterior Segment Surgery: A Comprehensive Review of Pathophysiology, Clinical Features, and Recovery Time Course.Life (Basel, Switzerland) · 2026Review
- Evaluating Lacrimal Punctum Size as a Clinical Indicator of Dry Eye Disease Severity in a Real-World Lebanese Cohort.Journal of clinical medicine · 2026Article
- Inflammatory and Anti-Inflammatory Response of the Ocular Surface After Excimer Laser Treatment.Biomedicines · 2026Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Tears have a vital function to protect and lubricate the ocular surface. Tear production, distribution and clearance is tightly regulated by the lacrimal functional unit (LFU) to meet ocular surface demands. The tear film consists of an aqueous-mucin layer, containing fluid and soluble factors produced by the lacrimal glands and mucin secreted by the goblet cells, that is covered by a lipid layer. The array of proteins, glycoproteins and lipids in tears function to maintain a stable, well-lubricated and smooth optical surface. Tear factors also promote wound healing, suppress inflammation, scavenge free radicals, and defend against microbial infection. Disease and dysfunction of the LFU leads to tear instability, increased evaporation, inflammation, and blurred and fluctuating vision. The function of tear components and the consequences of tear deficiency on the ocular surface are reviewed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.