Evidence map›Paper›PMID 32565723›Full record

ArticleMediators of inflammation2020

The Effects of Sidt2 on the Inflammatory Pathway in Mouse Mesangial Cells.

Hui Sun, Jia-Ming Ding, Hui-Hao Zheng, Kang-Jia Lv, Yun-Fei Hu, Ying-Hui Luo, Xue Wu, Wen-Jun Pei, Li-Zhuo Wang, Ming-Cai Wu and 2 more

Abstract read
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. [Lysosomal membrane proteinNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  4. Modified Gexiazhuyu decoction alleviates chronic salpingitis p38 signaling pathway.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hui SunDepartment of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu 241002, China.
Jia-Ming DingSchool of Clinical Medicine, Wannan Medical College, Wuhu 241002, China.
Hui-Hao ZhengSchool of Medical Imaging, Wannan Medical College, Wuhu 241002, China.
Kang-Jia LvSchool of Clinical Medicine, Wannan Medical College, Wuhu 241002, China.
Yun-Fei HuDepartment of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu 241002, China.
Ying-Hui LuoSchool of Pharmacy, Wannan Medical College, Wuhu 241002, China.
Xue WuDepartment of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu 241002, China.
Wen-Jun PeiAnhui Province Key Laboratory of Biological Macro-molecules Research, Wannan Medical College, Wuhu 241001, China.
Li-Zhuo WangInstitute of Endocrine and Metabolic Diseases, Yijishan Hospital of Wannan Medical College, Wuhu 241002, China.
Ming-Cai WuDepartment of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu 241002, China.
Yao ZhangAnhui Province Key Laboratory of Biological Macro-molecules Research, Wannan Medical College, Wuhu 241001, China.
Jia-Lin GaoDepartment of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu 241002, China.ORCID https://orcid.org/0000-0001-7669-2785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with chronic kidney disease, the abnormal activation of inflammatory pathways is usually an important factor leading to renal fibrosis and further deterioration of renal function. Finding effective intervention targets of the inflammatory signaling pathway is an important way to treat chronic kidney disease. As a newly discovered lysosomal membrane protein, the correlation between SID1 transmembrane family member 2 (Sidt2) and the inflammatory signaling pathway has not been reported. The aim of this study was to investigate the effect of Sidt2 on inflammation by inhibiting the expression of the

Indexed as

Gene Expression ProfilingAnimalsCRISPR-Cas SystemsCytokinesGene Expression RegulationGlomerular Filtration RateI-kappa B KinaseInflammationLentivirusLipopolysaccharidesLysosomesMAP Kinase Signaling SystemMesangial CellsMiceMice, KnockoutNF-KappaB Inhibitor alphaCytokinesI-kappa B KinaseLipopolysaccharidesNF-KappaB Inhibitor alphaNucleotide Transport ProteinsRela protein, mouseSidt2 protein, mouseTranscription Factor RelATumor Necrosis Factor-alpha

Identifiers

PMID32565723
PMCPMC7275211

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.