Evidence mapPaperPMID 32569476Full record

ReviewExpert review of medical devices2020

Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy.

Julia Fuchs, Roman Hovorka

Registry-linked trialAbstract readReview
In one paragraph

Review in Expert review of medical devices, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07348432 (The diabEAT Study), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07348432 recruitingnot on this mapstarted 2024, after this paper: background citation

The diabEAT Study: Insulin dElivery Technologies And eaTing Behaviours in People With Type 1 Diabetes

TypeobservationalSponsorMcGill UniversityRan2024 to 2026Enrolled106ConditionsInsulin Dependent Diabetes Mellitus, Feeding and Eating Disorders, Eating Behavior, Type 1 DiabetesArmsAutomated Insulin Delivery (AID) Systems, Carbohydrate Counting Inaccuracy Percentage
3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Recent advances in the precision control strategy of artificial pancreas.Medical & biological engineering & computing · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Virtual twin for healthcare management.Frontiers in digital health · 2023
    Article
  20. Type 1 diabetes - What's new in prevention and therapeutic strategies?Pediatric endocrinology, diabetes, and metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julia FuchsWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge , Cambridge, UK.
Roman HovorkaWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge , Cambridge, UK.ORCID https://orcid.org/0000-0003-2901-461X

Funding

University of Southern California Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) Resource Center for Minority Aging Research (USC AD/ADRD RCMAR)P30AG043073 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$717k
Department of Health 14/23/09NIA NIH HHS P30 AG043073NIDDK NIH HHS DP3 DK112176NIDDK NIH HHS UC4 DK108520
6 · The paper itself

Abstract

introductionType 1 diabetes is a lifelong disease with high management burden. The majority of people with type 1 diabetes fail to achieve glycemic targets. Algorithm-driven automated insulin delivery (closed-loop) systems aim to address these challenges. This review provides an overview of commercial and emerging closed-loop systems. AREAS COVERED: We review safety and efficacy of commercial and emerging hybrid closed-loop systems. A literature search was conducted and clinical trials using day-and-night closed-loop systems during free-living conditions were used to report on safety data. We comment on efficacy where robust randomized controlled trial data for a particular system are available. We highlight similarities and differences between commercial systems. EXPERT OPINION: Study data shows that hybrid closed-loop systems are safe and effective, consistently improving glycemic control when compared to standard therapy. While a fully closed-loop system with minimal burden remains the end-goal, these hybrid closed-loop systems have transformative potential in diabetes care.

Indexed as

AlgorithmsBlood GlucoseDiabetes Mellitus, Type 1Health PersonnelHumansInsulin Infusion SystemsTreatment OutcomeBlood GlucoseArtificial pancreasautomated insulin deliveryclosed-loopcontinuous glucose monitoringinsulin pumptype 1 diabetes

Identifiers

PMID32569476
PMCPMC7441745

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.