Evidence map›Paper›PMID 32576859›Full record

ArticleScientific reports2020

Hyaloid vasculature and mmp2 activity play a role during optic fissure fusion in zebrafish.

Megan L Weaver, Warlen P Piedade, Nishita N Meshram, Jakub K Famulski

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. An Overview towards Zebrafish Larvae as a Model for Ocular Diseases.International journal of molecular sciences · 2023
    Review
  2. Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure.Investigative ophthalmology & visual science · 2022
    Article
  3. Article
  4. Pax2a, but not pax2b, influences cell survival and periocular mesenchyme localization to facilitate zebrafish optic fissure closure.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  5. Review
  6. Article
  7. Eyes on CHARGE syndrome: Roles of CHD7 in ocular development.Frontiers in cell and developmental biology · 2022
    Review
  8. Review
  9. Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Megan L WeaverDepartment of Biology, University of Kentucky, Lexington, KY, USA.
Warlen P PiedadeDepartment of Biology, University of Kentucky, Lexington, KY, USA.
Nishita N MeshramDepartment of Biology, University of Kentucky, Lexington, KY, USA.
Jakub K FamulskiDepartment of Biology, University of Kentucky, Lexington, KY, USA. jkfa226@uky.edu.
University of Kentucky · US

Funding

Comprehensive analysis of periocular mesenchyme composition, specification and function during anterior segment formationR01EY027805 · NEI · UNIVERSITY OF KENTUCKY · PI FAMULSKI, JAKUB K · 2018 to 2022
$1.9M
NEI NIH HHS R01 EY027805
6 · The paper itself

Abstract

Vertebrate retinal development requires timely and precise fusion of the optic fissure (OF). Failure of this event leads to congenital vision impairment in the form of coloboma. Recent studies have suggested hyaloid vasculature to be involved in OF fusion. In order to examine this link, we analyzed OF fusion and hyaloid vasculogenesis in the zebrafish pax2a noi mutant line. We first determined that pax2a

Indexed as

Embryo, NonmammalianAnimalsBasement MembraneColobomaEyeGene ExpressionGene Expression Regulation, DevelopmentalMatrix Metalloproteinase 2MorphogenesisMutationPAX2 Transcription FactorRetinaZebrafishZebrafish ProteinsMatrix Metalloproteinase 2pax2a protein, zebrafishPAX2 Transcription FactorZebrafish Proteins

Identifiers

PMID32576859
PMCPMC7311462
OpenAlexW3035781820

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.