Evidence mapPaperPMID 32578465Full record

SynthesisJournal of the American Heart Association2020

Future Cardiovascular Disease Risk for Women With Gestational Hypertension: A Systematic Review and Meta-Analysis.

Charmaine Chu Wen Lo, Andre C Q Lo, Shu Hui Leow, Grace Fisher, Beth Corker, Olivia Batho, Bethan Morris, Monika Chowaniec, Catherine J Vladutiu, Abigail Fraser and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Trial
  7. Article
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  11. The Impact of Nurse Home-Visiting for Pregnant and Parenting Individuals with Previous Live Births.Prevention science : the official journal of the Society for Prevention Research · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. Journal of mother and child · 2026
    Article
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  17. Review
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Charmaine Chu Wen LoFaculty of Health and Medicine University of Newcastle New South Wales Australia.
Andre C Q LoHomerton College University of Cambridge United Kingdom.
Shu Hui LeowHomerton College University of Cambridge United Kingdom.
Grace FisherHills Road Sixth Form College Cambridge United Kingdom.
Beth CorkerHomerton College University of Cambridge United Kingdom.
Olivia BathoHomerton College University of Cambridge United Kingdom.
Bethan MorrisHomerton College University of Cambridge United Kingdom.
Monika ChowaniecHomerton College University of Cambridge United Kingdom.
Catherine J VladutiuDepartment of Obstetrics & Gynecology School of Medicine University of North Carolina Chapel Hill NC.
Abigail FraserPopulation Health Sciences Bristol Medical School University of Bristol United Kingdom.
Clare Oliver-WilliamsHomerton College University of Cambridge United Kingdom.
University of Cambridge · GBLiverpool Hospital · AUThe Sixth Form College Colchester · GBUniversity of Bristol · GBUniversity of North Carolina at Chapel Hill · US

Funding

British Heart Foundation RE/13/6/30180Medical Research Council MR/M009351/1
6 · The paper itself

Abstract

Background Inconsistent findings have been found among studies evaluating the risk of cardiovascular disease for women who have had pregnancies complicated by gestational hypertension (the new onset of high blood pressure without proteinuria during pregnancy). We provide a comprehensive review of studies to quantify the association between gestational hypertension and cardiovascular events in women. Methods and Results We conducted a systematic search of PubMed, Embase, and Web of Science in March 2019 for studies examining the association between gestational hypertension and any cardiovascular event. Two reviewers independently assessed the abstracts and full-text articles. Study characteristics and the relative risk (RR) of cardiovascular events associated with gestational hypertension were extracted from the eligible studies. Where appropriate, the estimates were pooled with inverse variance weighted random-effects meta-analysis. A total of 21 studies involving 3 60 1192 women (127 913 with gestational hypertension) were identified. Gestational hypertension in the first pregnancy was associated with a greater risk of overall cardiovascular disease (RR, 1.45; 95% CI, 1.17-1.80) and coronary heart disease (RR, 1.46; 95% CI, 1.23-1.73), but not stroke (RR, 1.26; 95% CI, 0.96-1.65) or thromboembolic events (RR, 0.88; 95% CI, 0.73-1.07). Women with 1 or more pregnancies affected by gestational hypertension were at greater risk of cardiovascular disease (RR, 1.81; 95% CI, 1.42-2.31), coronary heart disease (RR, 1.83; 95% CI, 1.33-2.51), and heart failure (RR, 1.77; 95% CI, 1.47-2.13), but not stroke (RR, 1.50; 95% CI, 0.75-2.99). Conclusions Gestational hypertension is associated with a greater risk of overall cardiovascular disease, coronary heart disease, and heart failure. More research is needed to assess the presence of a dose-response relationship between gestational hypertension and subsequent cardiovascular disease. Registration URL: https://www.crd.york.ac.uk/prosp​ero/; Unique identifier: CRD42018119031.

Indexed as

AdolescentAdultBlood PressureCardiovascular DiseasesCoronary DiseaseFemaleHeart Disease Risk FactorsHeart FailureHumansHypertension, Pregnancy-InducedMiddle AgedPregnancyPrognosisRisk AssessmentYoung Adultcardiovascular diseasegestational hypertensionpregnancyreviewwomen

Identifiers

PMID32578465
PMCPMC7670531
OpenAlexW3025636277

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.