Evidence map›Paper›PMID 32582833›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020

Cerebrospinal fluid irisin correlates with amyloid-β, BDNF, and cognition in Alzheimer's disease.

Mychael V Lourenco, Felipe C Ribeiro, Felipe K Sudo, Cláudia Drummond, Naima Assunção, Bart Vanderborght, Fernanda Tovar-Moll, Paulo Mattos, Fernanda G De Felice, Sergio T Ferreira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
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  7. Article
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  10. The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia.Annals of clinical and translational neurology · 2025
    Article
  16. Review
  17. Review
  18. Increasing the health span: unique role for exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mychael V LourencoInstitute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro Cidade Universitaria - Rio de Janeiro Rio de Janeiro Brazil.
Felipe C RibeiroInstitute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro Cidade Universitaria - Rio de Janeiro Rio de Janeiro Brazil.
Felipe K SudoD'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil.
Cláudia DrummondD'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil.
Naima AssunçãoD'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil.
Bart VanderborghtD'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil.
Fernanda Tovar-MollD'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil.
Paulo MattosD'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil.
Fernanda G De FeliceInstitute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro Cidade Universitaria - Rio de Janeiro Rio de Janeiro Brazil.
Sergio T FerreiraInstitute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro Cidade Universitaria - Rio de Janeiro Rio de Janeiro Brazil.
Universidade Federal do Rio de Janeiro · BRD’Or Institute for Research and Education · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIrisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and rescue memory in mouse models of Alzheimer's disease (AD). However, whether and how cerebrospinal fluid (CSF) irisin varies in relation to canonical AD biomarkers and cognition in humans remains unknown.

methodsWe determined CSF levels of irisin and brain-derived neurotrophic factor (BDNF) and examined their correlations with CSF amyloid beta (Aβ)

resultsCSF irisin correlated positively with BDNF, Aβ DISCUSSION: Results indicate that CSF irisin and BDNF are directly correlated with Aβ pathology and cognition in AD.

Indexed as

Alzheimer's diseaseBDNFcerebrospinal fluiddementiaFNDC5irisin

Identifiers

PMID32582833
PMCPMC7306518
OpenAlexW3036217219

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.